Periodontal regenerative effect by inhibition of Sprout2 protein.
| Project/Area Number |
22792092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯周組織再生 / Sprouty2 / 骨芽細胞 / 上皮細胞 / bFGF / EGF |
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| Research Abstract |
Sprouty2 functions as a negative regulator of receptor tyrosine kinases(RTKs) signaling. The purpose of this study was to investigate whether Sprouty2 could be new therapeutic targets for periodontal tissue regeneration. Suppression of Sprouty2 induced cell proliferation and differentiation of osteoblastic cells, while it diminished cell proliferation of gingival epithelial cells. In other words, inhibition of Sprouty2 may effectively allow alveolar bone to grow, with blocking the ingrowth of gingival epithelial cells toward bony defects, as well as an effect of guided tissue regeneration(GTR) methods
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Report
(3 results)
Research Products
(16 results)
