Periodontal regenerative effect by inhibition of Sprout2 protein.

• Project/Area Number: 22792092
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Kyushu University
• Principal Investigator: SANUI Terukazu 九州大学, 歯学研究院, 助教 (70507780)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯周組織再生 / Sprouty2 / 骨芽細胞 / 上皮細胞 / bFGF / EGF

Research Abstract

Sprouty2 functions as a negative regulator of receptor tyrosine kinases(RTKs) signaling. The purpose of this study was to investigate whether Sprouty2 could be new therapeutic targets for periodontal tissue regeneration. Suppression of Sprouty2 induced cell proliferation and differentiation of osteoblastic cells, while it diminished cell proliferation of gingival epithelial cells. In other words, inhibition of Sprouty2 may effectively allow alveolar bone to grow, with blocking the ingrowth of gingival epithelial cells toward bony defects, as well as an effect of guided tissue regeneration(GTR) methods

Research Products

• [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling (2011)
  • Author(s): Matsumura K, Taketomi T, Yoshizaki K, Arai S, Sanui T, Yoshiga D, Yoshimura A, Nakamura S
  • Journal Title: Biochemal Biophysical Research Communications Volume: 404(4) Pages: 1076-1082
  • Peer Reviewed
• [Journal Article] 研究プロジェクトの精鋭たち/わが医局のエース (2011)
  • Author(s): 讃井彰一・前田勝正
  • Journal Title: ザ・クインテッセンス Volume: 30巻 Pages: 200-201
• [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling. (2011)
  • Author(s): Matsumura K, Taketomi T, Yoshizaki K, Arai S, Sanui T, Yoshiga D, Yoshimura A, Nakamura S
  • Journal Title: Biochemical Biophysical Research Communications Volume: 404 Pages: 1076-1082
  • Peer Reviewed
• [Presentation] Sprouty2分子を標的とした歯周組織再生の可能性平成23年度日本歯周病学会九州五大学 (2011)
  • Author(s): 田中麗
  • Organizer: 日本臨床歯周病学会九州支部合同研修会
  • Place of Presentation: 長崎県歯科医師会会館
  • Year and Date: 2011-11-20
• [Presentation] Sprouty2分子を標的とした歯周組織再生の可能性 (2011)
  • Author(s): 田中麗
  • Organizer: 平成23年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
  • Place of Presentation: 長崎県歯科医師会会館(長崎)
  • Year and Date: 2011-11-20
• [Presentation] ヒトY-box結合タンパク(YB-1)の骨芽細胞における細胞動態解析 (2011)
  • Author(s): 福田隆男
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 海峡メッセ下関
  • Year and Date: 2011-09-24
• [Presentation] ヒトY-box結合タンパク(YB-1)の骨芽細胞における細胞動態解析 (2011)
  • Author(s): 福田隆男
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 海峡メッセ下関(山口)
  • Year and Date: 2011-09-24
• [Presentation] Sprouty2 controls the palate mesenchymal cell proliferation via FGF signaling (2011)
  • Author(s): K. MATSUMURA
  • Organizer: The 89th General Session and Exhibition of the IADR
  • Place of Presentation: San Diego
  • Year and Date: 2011-03-17
• [Presentation] Characterization of the amelogenin binding proteins (2010)
  • Author(s): Takao Fukuda
  • Organizer: 96th AAP annual meeting
  • Place of Presentation: Hawaii
  • Year and Date: 2010-11-01
• [Presentation] Suppression of Sprouty2 Induces Periodontal Tissue Regeneration (2010)
  • Author(s): T. SANUI
  • Organizer: The 88th General Session and Exhibition of the IADR
  • Place of Presentation: Barcelona
  • Year and Date: 2010-07-16
• [Presentation] YB-1 is important for amelogenin induced periodontal regeneration (2010)
  • Author(s): T. FUKUDA
  • Organizer: The 88th General Session and Exhibition of the IADR
  • Place of Presentation: Barcelona
  • Year and Date: 2010-07-16
• [Presentation] Sprouty2 accelerates the growth of ameloblastoma with EGF stimulation (2010)
  • Author(s): T. TAKETOMI
  • Organizer: The 88th General Session and Exhibition of the IADR
  • Place of Presentation: Barcelona
  • Year and Date: 2010-07-16
• [Presentation] Spry2 deficient mice exhibit cleft palate (2010)
  • Author(s): K. MATSUMURA
  • Organizer: The 88th General Session and Exhibition of the IADR
  • Place of Presentation: Barcelona
  • Year and Date: 2010-07-16
• [Presentation] Suppression of Sprouty2 induces periodontal tissue regeneration. (2010)
  • Author(s): Terukazu Sanui
  • Organizer: The 88th International Association for Dental Research General Session
  • Place of Presentation: Center Conventions International Barcelona
  • Year and Date: 2010-07-16
• [Remarks]
  • URL: http://www.dent.kyushu-u.ac.jp/perio/
• [Remarks]
  • URL: http://www.dent.kyushu-u.ac.jp/perio/