Examination of pathogenesis of periodontal disease through ascorbic acid transporter SVCTs

• Project/Area Number: 22792099
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: IWASAKI Kengo 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教員 (40401351)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 幹細胞 / アスコルビン酸代謝 / 歯根膜 / 歯周組織 / 再生

Research Abstract

Ascorbic acid is water-soluble vitamin which has important role in collagen metabolism. This study revealed that SVCTs, ascorbic acid transporter, expressed widely in collagen-rich connective tissue, periodontal ligament. This result suggests that SVCT may contribute to keeping of homeostasis of periodontal tissues and to pathogenesis of periodontal disease.

Research Products

• [Journal Article] Comparison of characteristics of periodontal ligament cells obtained from outgrowth and enzyme-digested culturemethods (2011)
  • Author(s): Tanaka K, Iwasaki K, Feghali KE, Komaki M, Ishikawa I, Izumi Y
  • Journal Title: Archives of Oral Biology Volume: 56巻 Pages: 380-388
  • Peer Reviewed
• [Journal Article] Comparison of characteristics of periodontal ligament cells obtained from outgrowth and enzyme-digested culture methods. (2011)
  • Author(s): Tanaka K, Iwasaki K, Feghali KE, Komaki M, Ishikawa I, Izumi Y.
  • Journal Title: Archives of Oral Biology Volume: 56巻 Pages: 380-388
  • Peer Reviewed
• [Presentation] 歯根膜幹細胞転写羊膜を用いた歯周組織再生治療の可能性について (2011)
  • Author(s): 岩崎剣吾
  • Organizer: 第54回秋季日本歯周病学会学術大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-24
• [Presentation] 細胞培養による歯根膜幹細胞の血管平滑筋様変化について (2011)
  • Author(s): 岩崎剣吾
  • Organizer: 第54回春季日本歯周病学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-28
• [Presentation] 培養歯根膜幹細胞のpericyteとしての機能解析 (2010)
  • Author(s): 岩崎剣吾
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松
  • Year and Date: 2010-09-18