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Elucidation of mechanism of developing the periodontitis at the host-parasite interface

Research Project

Project/Area Number 22792104
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionTohoku University

Principal Investigator

MAYANAGI Gen  東北大学, 大学院・歯学研究科, 助教 (10451600)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細菌学 / 免疫学 / 遺伝学 / 歯周病学
Research Abstract

Analyzing the subgingival plaque and the gingival tissues samples, it was elucidated that the deeper the periodontal pocket the patient has, the larger the amounts of the anaerobic bacteria and the inflammatory cytokines were detected. It is possible to evaluate the profiles of the clinical conditions of periodontitis in the initial preparation stage from the views of microbiology and immunology. In the future, we will be able to provide the effective treatment for the periodontitis patient by profiling the amounts of the anaerobic bacteria and the inflammatory cytokines.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (40 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (27 results) Book (4 results)

  • [Journal Article] Metabolomic approach to oral biofilm characterization - A future direction of biofilm research.2012

    • Author(s)
      Takahashi N, Washio J, Mayanagi G
    • Journal Title

      J Oral Biosci

      Volume: 54 Issue: 3 Pages: 138-143

    • DOI

      10.1016/j.job.2012.02.005

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a coating resin containing S-PRG filler to prevent demineralization of root surfaces2012

    • Author(s)
      Ma S, Imazato S, Chen J-H, Mayanagi G, Takahashi N, Ishimoto T, Nakano T
    • Journal Title

      Dental Materials Journal

      Volume: 31 Issue: 6 Pages: 909-915

    • DOI

      10.4012/dmj.2012-061

    • NAID

      10031126068

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microflora profiling of infected root canal before and after treatment using culture-independent methods2012

    • Author(s)
      Ito Y, Sato T, Yamaki K, Mayanagi G, Hashimoto K, Shimauchi H, Takahashi N
    • Journal Title

      J Microbiol

      Volume: 50(1) Issue: 1 Pages: 58-62

    • DOI

      10.1007/s12275-012-0459-4

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of pH at the bacteria-dental cement interface2011

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Journal Title

      J Dent Res

      Volume: 90(12) Issue: 12 Pages: 1446-1450

    • DOI

      10.1177/0022034511423392

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolomics of supragingival plaque and oral bacteria2010

    • Author(s)
      Takahashi N, Washio J, Mayanagi G
    • Journal Title

      J Dent Res

      Volume: 89(12) Issue: 12 Pages: 1383-1388

    • DOI

      10.1177/0022034510377792

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR2010

    • Author(s)
      Abiko Y, Sato T, Mayanagi G, Takahashi N
    • Journal Title

      J Periodont Res

      Volume: 45(3) Issue: 3 Pages: 389-395

    • DOI

      10.1111/j.1600-0765.2009.01250.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] New Strategy of Study for Oral Microbiology! Challenge to Metabolomics of Oral Biofilm-From "What Are They" to "What Are They Doing?" -2010

    • Author(s)
      Washio J, Mayanagi G, Takahashi N
    • Journal Title

      Journal of Oral Biosciences

      Volume: 52巻 Issue: 3 Pages: 225-232

    • DOI

      10.1016/s1349-0079(10)80025-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR2010

    • Author(s)
      Abiko Y, Sato T, Mayanagi G, Takahashi N
    • Journal Title

      Journal of Periodontal Research

      Volume: 45 Pages: 389-395

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (Review : New strategy of study for oral microbiology) Challenge to metabolomics of oral biofilm-from "what are they?" to "what are they doing?"-2010

    • Author(s)
      Washio J, Mayanagi G, Takahashi N
    • Journal Title

      Journal of Oral Biosciences

      Volume: 52 Pages: 225-232

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Stephan curve and tooth surface solubility at tooth-bacteria interface2013

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Takahashi N
    • Organizer
      The 91th International Association for Dental Research (IADR)
    • Place of Presentation
      Washington State Convention Center, Seattle, WA, USA
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] The biocorrosion behavior of titanium under artificial biofilm2013

    • Author(s)
      Fukushima A, Mayanagi G, Nakajo K, Sasaki K, Takahashi N
    • Organizer
      The 91th International Association for Dental Research (IADR)
    • Place of Presentation
      Washington State Convention Center, Seattle, WA, USA
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] S.mutans人工バイオフィルムによるチタンの生物学的腐食2013

    • Author(s)
      福島梓、真柳弦、中條和子、佐々木啓一、高橋信博
    • Organizer
      第5回口腔環境制御研究カテゴリー集会
    • Place of Presentation
      長崎大学
    • Year and Date
      2013-02-01
    • Related Report
      2012 Final Research Report
  • [Presentation] S. mutans人工バイオフィルムによるチタンの生物学的腐食2013

    • Author(s)
      福島梓、真柳弦、中條和子、佐々木啓一、高橋信博
    • Organizer
      第5回口腔環境制御研究カテゴリー集会
    • Place of Presentation
      長崎大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stephan Curve and Tooth Surface Solubility at Tooth-bacteria Interface2013

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Takahashi N
    • Organizer
      The 91th International Association for Dental Research (IADR)
    • Place of Presentation
      Washington State Convention Center, Seattle, WA, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of a coating resin containing S-PRG filler to prevent demineralization of root surfaces2012

    • Author(s)
      Ma S, Imazato S, Chen J-H, Mayanagi G, Takahashi N, Ishimoto T, Nakano T
    • Organizer
      日中歯科医学大会 2012
    • Place of Presentation
      四川大学華西口腔医学院、中国
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] バイオマテリアル-パラサイト・インターフェイスへの挑戦-バイオマテリアルの生物学的劣化の理解へ-2012

    • Author(s)
      高橋信博、真柳弦、中條和子、鷲尾純平、佐藤拓一、竹内裕尚、佐久間陽子、松尾洋、末永華子、鈴木治、佐々木啓一
    • Organizer
      九州大学応用力学研究所平成23年度共同利用研究集会「力学適応能、自己組織化能を有するバイオマテリアル-生体インターフェイスの創製」
    • Place of Presentation
      九州大学
    • Year and Date
      2012-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] バイオマテリアルーパラサイト・インターフェイスへの挑戦-バイオマテリアルの生物学的劣化の理解へ-2012

    • Author(s)
      高橋信博, 真柳弦, 中條和子, 鷲尾純平, 佐藤拓一, 竹内裕尚, 佐久間陽子, 松尾洋, 末永華子, 鈴木治, 佐々木啓一
    • Organizer
      九州大学応用力学研究所平成23年度共同利用研究集会「力学適応能、自己組織化能を有するバイオマテリアル-生体インターフェイスの創製」
    • Place of Presentation
      福岡
    • Year and Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of a coating resin containing S-PRG filler to prevent demineralization of root surfaces2012

    • Author(s)
      Ma S, Imazato S, Chen J-H, Mayanagi G, Takahashi N, Ishimoto T, Nakano T
    • Organizer
      日中歯科医学大会2012
    • Place of Presentation
      四川大学華西口腔医学院、中国
    • Related Report
      2012 Annual Research Report
  • [Presentation] CE-TOFMSを用いた口腔プラークバイオフィルムの糖代謝メタボローム解析~フッ化物やキシリトールによる影響をin vivoで探る~2011

    • Author(s)
      鷲尾純平、小川珠生、真柳弦、高橋信博
    • Organizer
      キャピラリー電気泳動シンポジウム
    • Place of Presentation
      鶴岡
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] CE-TOFMSを用いた口腔プラークバイオフィルムの糖代謝メタボローム解析~フッ化物やキシリトールによる影響をin vivoで探る~2011

    • Author(s)
      鷲尾純平, 小川珠生, 真柳弦, 高橋信博
    • Organizer
      第31回キャピラリー電気泳動シンポジウム
    • Place of Presentation
      鶴岡
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] イオン感受性電界効果型トランジスタ微小pH電極による細菌-歯科修復材料・インターフェイスpH測定2011

    • Author(s)
      真柳弦、五十嵐公英、鷲尾純平、中條和子、土門-俵谷ひと美、高橋信博
    • Organizer
      粉体粉末冶金協会平成23年度秋季大会(第108回講演大会)
    • Place of Presentation
      大阪大学
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] イオン感受性電界効果型トランジスタ微小pH電極による細菌-歯科修復材料・インターフェイスpH測定2011

    • Author(s)
      真柳弦, 五十嵐公英, 鷲尾純平, 中條和子, 土門-俵谷ひと美, 高橋信博
    • Organizer
      粉体粉末冶金協会平成23年度秋季大会(第108回講演大会)
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Domon-Tawaraya H, Takahashi N, Evaluation of pH at the bacteria-restorative materialinterface2011

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K
    • Organizer
      第59回JADR学術大会
    • Place of Presentation
      広島
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of pH at the bacteria-restorative material interface2011

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Organizer
      第59回JADR学術大会
    • Place of Presentation
      広島
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of pH using an ISFET at the interface between bacteria and restorative materials2011

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Organizer
      The 6^<th> International Workshop on Nano-, Bio- and Amorphous Materials
    • Place of Presentation
      遠刈田
    • Year and Date
      2011-08-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of pH using an ISFET at the interface between bacteria and restorative materials2011

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Organizer
      The 6th International Workshop on Nano-, Bio- and Amorphous Materials
    • Place of Presentation
      宮城蔵王ロイヤルホテル
    • Year and Date
      2011-08-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of pH at the interface between bacteria and restorative materials2011

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science
    • Place of Presentation
      仙台
    • Year and Date
      2011-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Metabolome analysis of oral plaque biofilm using CE-TOFMS2011

    • Author(s)
      Washio J, Mayanagi G, Takahashi N
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science
    • Place of Presentation
      仙台
    • Year and Date
      2011-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of pH at the interface between bacteria and restorative materials2011

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science
    • Place of Presentation
      ホテル仙台プラザ(宮城県)
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Metabolome analysis of oral plaque biofilm using CE-TOFMS2011

    • Author(s)
      Washio J, Mayanagi G, Takahashi N
    • Organizer
      The 4^<th> International Symposium for Interface Oral Health Science
    • Place of Presentation
      ホテル仙台プラザ(宮城県)
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] プラークバイオフィルムのメタボローム解析-糖代謝からアミノ酸代謝まで-2010

    • Author(s)
      鷲尾純平、真柳弦、高橋信博
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      船堀
    • Year and Date
      2010-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] プラークバイオフィルムのメタボローム解析-糖代謝からアミノ酸代謝まで-2010

    • Author(s)
      鷲尾純平, 真柳弦, 高橋信博
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of pH using an ISFET at theparasite-biomaterial interface2010

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Organizer
      The 5^<th> International Workshop on Nano, Bio andAmorphous Materials
    • Place of Presentation
      遠刈田
    • Year and Date
      2010-08-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of pH using an ISFET at the parasite-biomaterial interface2010

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Organizer
      International Workshop on Nano, Bio and Amorphous Materials
    • Place of Presentation
      さんさ亭(宮城県)
    • Year and Date
      2010-08-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Metabolome analysis of glucose fermentation by dental plaque using CE-TOFMS2010

    • Author(s)
      Washio J, Mayanagi G, Sakurada K, Sato K, Katsuda Y, Tsuji N, Hata T, Takahashi N
    • Organizer
      The 88^<th> International Association for Dental Research
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Metabolome analysis of glucose fermentation by dental plaque using CE-TOFMS2010

    • Author(s)
      Washio J, Mayanagi G, Katsuda Y, Hata T, Sakurada K, Sato K, Tsuji N, Takahashi N
    • Organizer
      The 88th International Association for Dental Research
    • Place of Presentation
      The Centre Convencions Internacional Barcelona (Barcelona, Spain)
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Book] Evaluation of pH at the interface between bacteria and restorative materials, In: K. Sasaki, O. Suzuki, N. Takahashi (eds.) Interface Oral Health Science 20112012

    • Author(s)
      Mayanagi G, Igarashi K, Washio J, Nakajo K, Domon-Tawaraya H, Takahashi N
    • Publisher
      Springer社
    • Related Report
      2012 Final Research Report
  • [Book] Metabolome analysis of oral plaque biofilm using CE-TOFMS, In: K. Sasaki, O.Suzuki, N. Takahashi (eds.) Interface OralHealth Science 20112012

    • Author(s)
      Washio J, Mayanagi G, Takahashi N
    • Publisher
      Springer社
    • Related Report
      2012 Final Research Report
  • [Book] Metabolomic approach to oral microbiota, In: K. Sasaki, O. Suzuki, N. Takahashi (eds.) Interface Oral Health Science 20112012

    • Author(s)
      Takahashi N, Washio J, Mayanagi G
    • Publisher
      Springer社
    • Related Report
      2012 Final Research Report
  • [Book] Interface Oral Health Science 20112012

    • Author(s)
      K.Sasaki, O.Suzuki, N.Takahashi, 他
    • Publisher
      Springer, Tokyo
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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