Effects of non-surgical periodontal treatment on oxidative stress

• Project/Area Number: 22792119
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: TAMAKI Naofumi 岡山大学, 岡山大学病院, 講師 (20335615)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 歯周病 / 酸化ストレス / 抗酸化力 / 肝細胞がん / 肝細胞癌 / JISスコア

Research Abstract

Periodontitis induces overproduction of reactive oxygen species(ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma(HCC). The Japan Integrated Stage(JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis. We recruited 64 HCC patients comprising 31 chronic periodontitis subjects(HCC+ P) and 33 periodontally healthy controls(HCC+ H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites(ROM) from HCC+ P, HCC+ H were also assessed for circulating ROS levels. The HCC+ P group showed higher JIS scores than the HCC+ H group. Serum levels of ROM in the HCC+ P group were a further 25. 8% higher than those in the HCC+ H group.

Research Products

• [Journal Article] Stage of hepatocellular carcinoma is associated with periodontitis (2011)
  • Author(s): Tamaki N、Takaki A、Tomofuji T、Endo Y、Kasuyama K、Ekuni D、Yasunaka T、Yamamoto K、Morita M
  • Journal Title: J Clin Periodontol Volume: 38巻11号 Pages: 1015-1020
  • NAID: 110009668603
  • Peer Reviewed
• [Journal Article] Periodontal treatment decreases plasma oxidized LDL level and oxidative stress (2011)
  • Author(s): Tamaki N、Tomofuji T、Ekuni D、Yamanaka R、Morita M
  • Journal Title: Clin Oral Investig Volume: 15巻6号 Pages: 953-958
  • Peer Reviewed
• [Journal Article] Periodontal treatment decreases plasma oxidized LDL level and oxidative stress (2011)
  • Author(s): Tamaki N
  • Journal Title: Clinical Oral Investigations Volume: 15 Issue: 6 Pages: 953-958
  • DOI: 10.1007/s00784-010-0458-y
  • Peer Reviewed
• [Journal Article] Stage of hepatocellular carcinoma is associated with periodontitis (2011)
  • Author(s): Tamaki N
  • Journal Title: Journal of Clinical Periodontology Volume: 38 Issue: 11 Pages: 1015-1020
  • DOI: 10.1111/j.1600-051x.2011.01777.x
  • NAID: 110009668603
  • Peer Reviewed
• [Journal Article] Periodontal treatment decreases plasma oxidized LDL level and oxidative stress (2010)
  • Author(s): Tamaki N
  • Journal Title: Clinical Oral Investigations
  • Peer Reviewed
• [Presentation] 歯周炎の状態と肝癌のステージとの関連についての研究 (2011)
  • Author(s): 玉木直文
  • Organizer: 第60回口腔衛生学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-10-09
• [Presentation] 歯周炎の状態と肝癌のステージとの関連についての研究 (2011)
  • Author(s): 玉木直文
  • Organizer: 日本口腔衛生学会
  • Place of Presentation: 松戸
  • Year and Date: 2011-10-09
• [Presentation] 肝細胞がんの進行度と歯周病の関連における酸化ストレスの影響 (2011)
  • Author(s): 玉木直文
  • Organizer: 第64回酸化ストレス学会
  • Place of Presentation: 北海道
  • Year and Date: 2011-07-01
• [Presentation] 肝細胞がんの進行度と歯周病の関連における酸化ストレスの影響 (2011)
  • Author(s): 玉木直文
  • Organizer: 酸化ストレス学会
  • Place of Presentation: 北海道
  • Year and Date: 2011-07-01
• [Presentation] Periodontal treatment decreases plasma level of oxLDL and oxidative stress (2010)
  • Author(s): Tamaki N
  • Organizer: 96th American academy of periodontology
  • Place of Presentation: Hawaii
  • Year and Date: 2010-11-01
• [Presentation] Periodontal treatment decreases plasma level of oxLDL andoxidative stress (2010)
  • Author(s): Tamaki N
  • Organizer: 96th American academy of periodontolog
  • Place of Presentation: ハワイ
  • Year and Date: 2010-10-30
• [Remarks]
  • URL: http://www.dent.okayama-u.ac.jp/yobou/index_sc_j.html
• [Remarks]
  • URL: http://www.dent.okayama-u.ac.jp/yobou/index_sc_j.html
• [Remarks]
  • URL: http://www.dent.okayama-u.ac.jp/yobou/index_sc_j.html