| Project/Area Number |
22792123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 揮発性硫化物 / 口腔粘膜上皮 / 生体防御機構 / チオールメチルトランスフェラーゼ / 無毒化 / チオールメチルトランスフェラーセ |
|---|
| Research Abstract |
This study verified the existence of the two enzymes[Thiomethyltransferase(TMT) and Thiosulfate sulfurtransferase(RHOD)], which decomposed volatile sulfide compounds(VSC) generated from oral bacteria, in oral mucosa. However, we have not succeeded to obtain the specific primers for RT-PCR to detect the gene expression of TMT and RHOD in oral keratinocyte until now, therefore, this study has not demonstrated the existence of the enzyme decomposing VSC in oral mucosa.
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