Study on host defensive system of oral mucosa to volatile sulfide compounds in oral cavity.

• Project/Area Number: 22792123
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: MINEOKA Tetsuro 九州歯科大学, 歯学部, 特別研修員 (50571402)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 揮発性硫化物 / 口腔粘膜上皮 / 生体防御機構 / チオールメチルトランスフェラーゼ / 無毒化 / チオールメチルトランスフェラーセ

Research Abstract

This study verified the existence of the two enzymes[Thiomethyltransferase(TMT) and Thiosulfate sulfurtransferase(RHOD)], which decomposed volatile sulfide compounds(VSC) generated from oral bacteria, in oral mucosa. However, we have not succeeded to obtain the specific primers for RT-PCR to detect the gene expression of TMT and RHOD in oral keratinocyte until now, therefore, this study has not demonstrated the existence of the enzyme decomposing VSC in oral mucosa.

Research Products

• [Journal Article] 若年層の女性を対象とした口臭に関する意識調査口臭への一般認識と対人行動についてのパイロット研究 (2011)
  • Author(s): 峰岡哲郎、粟野秀慈、吉田明弘、邵仁浩、濱嵜朋子、安細敏弘
  • Journal Title: 口腔衛生会誌 Volume: 61 Pages: 282-287
• [Journal Article] 若年層の女性を対象とした口臭の意識調査 (2011)
  • Author(s): 峰岡哲郎
  • Journal Title: 日本口腔衛生学会誌 Volume: 61 Pages: 282-287
  • Peer Reviewed
• [Presentation] 培養口腔ケラチノサイトにおけるneutral endopeptidaseとsubstance Pとの関係について (2011)
  • Author(s): 中田元希, 粟野秀慈, 木下直昌, 峰岡哲郎、吉田明弘、邵仁浩、安細敏弘
  • Organizer: 第71回九州歯科学会総会
  • Place of Presentation: 北九州
• [Presentation] 頬粘膜上皮で発現するメタロプロテアーゼ遺伝子に関するパイロット研究 (2011)
  • Author(s): 木下直昌、粟野秀慈、中田元希、吉田明弘、邵仁浩、峰岡哲郎、安細敏弘
  • Organizer: 第71回九州歯科学会総会
  • Place of Presentation: 北九州
• [Presentation] 粘膜上皮におけるメタロプロテアーゼの遺伝子発現レベルと歯周健康状態との関係 (2011)
  • Author(s): 木下直昌、粟野秀慈、中田元希、吉田明弘、邵仁浩、峰岡哲郎、安細敏弘
  • Organizer: 第60回日本口腔衛生学会総会
  • Place of Presentation: 松戸
• [Presentation] 培養口腔ケラチノサイトにおけるneutral endopeptidaseの作用について (2011)
  • Author(s): 中田元希、粟野秀慈、木下直昌、峰岡哲郎、吉田明弘、邵仁浩、安細敏弘
  • Organizer: 第60回日本口腔衛生学会総会
  • Place of Presentation: 松戸
• [Presentation] Neutral Endopeptidase and Endothelin-converting Enzyme in Human Buccal Mucosal Epithelium (2010)
  • Author(s): Kinoshita, N., Awano, S., Yoshida, A., Soh, I., Mineoka, T., and Ansai, T
  • Organizer: 58th Japanese Association for Dental Research
  • Place of Presentation: Kitakyushu
• [Presentation] Neutral Endopeptidase and Endothelin-converting Enzyme in Human Buccal Mucosal Epithelium. (2010)
  • Author(s): Kinoshita, N., Awano, S., Yoshida, A., Soh, I., Mineoka, T., Ansai, T.
  • Organizer: 58^<th> Japanese Association for Dental Research
  • Place of Presentation: Kitakyushu
• [Remarks]
  • URL: http://www.kenkoyobou.net/college/index.html