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Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rat

Research Project

Project/Area Number 22792127
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionNihon University

Principal Investigator

MIZOGUCHI Naoko  日本大学, 歯学部, ポスト・ドクトラル・フェロー (00548919)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords摂食嚥下障害 / パーキンソン病 / オーラルジスキネジア / 大脳基底核 / ドパミン神経系 / マルチ・チャネル・ユニット法
Research Abstract

The dopaminergic system in the ventrolateral portion of striatum(Svl), a part of basal ganglia, plays an important role in the regulation of orofacial movements : bilateral co-stimulation of both dopamine D1-like and D2-like receptors elicits repetitive jaw movements in rats. However, it is still unknown how activities of Svl neurons are modulated by activation of dopaminergic receptors. In the present study, we systematically injected apomorphine(2 mg/kg i. v.), a non-selective dopamine receptor agonist, that induced jaw movements under urethane anesthesia, and performed multi-channel unit recording from Svl neurons. According to the spike firing patterns, the Svl neurons were classified into two subtypes ; phasically active(PA) and tonically active(TA) neurons. The divergent effects of apomorphine on PA neurons in the Svl might reflect differential expression of D1-like and D2-like receptors in the middle spiny neurons. Apomorphine-induced suppression of TA neuron activities with decreased synchronized outputs is likely to reduce locally released acetylcholine, which may modulate apomorphine-induced jaw movements.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Spatiotemporal profiles of transcallosal connections in rat insular cortex revealed by in vivo optical imaging2012

    • Author(s)
      Fujita S, Kitayama T, Mizoguchi N, Oi Y, Koshikawa N, Kobayashi M.
    • Journal Title

      Neuroscience

      Volume: 206 Pages: 201-211

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal dynamics of long-term potentiation in rat insular cortex revealed by optical imaging2011

    • Author(s)
      Mizoguchi N, Fujita S, Koshikawa N, Kobayashi M.
    • Journal Title

      Neurobiol Learn Mem

      Volume: 96 Pages: 468-478

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal dynamics of long-term potentiation in rat insular cortex revealed by optical imaging2011

    • Author(s)
      Mizoguchi N
    • Journal Title

      Neurobiology of Learning and Memory

      Volume: 96 Pages: 468-478

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Spatiotemporal profiles of long-term potentiation in rat insular cortex : an optical imaging study2011

    • Author(s)
      Mizoguchi N, Fujita S, Koshikawa N, Kobayashi M.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC, U. S. A
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Spatiotemporal profiles of long-term potentiation in rat insular cortex : an optical imaging study2011

    • Author(s)
      N.MIZOGUCHI
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC(米国)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Apomorphineの線条体腹外側部ニューロンの活動に対する修飾作用2011

    • Author(s)
      納谷はるな、藤田智史、溝口尚子、越川憲明、小林真之
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Apomorphineの線条体腹外側部ニューロンの活動に対する修飾作用2011

    • Author(s)
      納谷はるな
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Place of Presentation
      長良川国際会議場(岐阜県)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pilocarpine-induced status epilepticus causes hyper-excitatory propagation and interneuron loss in rat agranular insular cortex2010

    • Author(s)
      Fujita S, Chen S, Mizoguchi N, Koshikawa N, Kobayashi M.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, U. S. A
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 社会福祉施設での摂食・嚥下障害に対する2年間の取り組み2010

    • Author(s)
      阿部仁子、溝口尚子、田尻陽子、飯田貴俊、戸原玄、植田耕一郎、市村志乃、斉藤朋子、米山佳代子
    • Organizer
      第16回日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Pilocarpine-induced status epilepticus causes hyper excitatory propagation and interneuron loss in rat agranular insular cortex.2010

    • Author(s)
      Fujita S, Chen S, Mizoguchi N, Koshikawa K, Kobayashi M
    • Organizer
      40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego(米国)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 社会福祉施設での摂食・嚥下障害に対する2年間の取り組み2010

    • Author(s)
      阿部仁子, 溝口尚子, 田尻陽子, 飯田貴俊, 戸原玄, 植田耕一郎, 市村志乃, 斉藤朋子, 米山佳代子
    • Organizer
      第16回日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県)
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.nihon-u.ac.jp/pharm/index.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.nihon-u.ac.jp/pharm/index.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.nihon-u.ac.jp/pharm/index.htm

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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