Functional proteomic analysis to identify memory formation-related proteins in the Drosophila mushroom bodies.
| Project/Area Number |
22800012
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Keywords | 記憶学習 / ショウジョウバエ / プロテオミクス / CREB / 記憶・学習 |
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| Research Abstract |
I started to develop the new methods to approach the molecular or cellular mechanisms underlying memory formation, storage, retrieval in this study. I tried to identify new factors related to learning and memory by proteomics analysis and then, I planed to determine the cells in which they would function. But I failed to establish the methods to concentrate the synapse-specific proteins. So I changed my approach into identify the cells recruited into memory traces. I generated CREB activity reporter flies and succeeded in labeling the cells in response to long-term memory formation.
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Report
(3 results)
Research Products
(2 results)
