| Budget Amount *help |
¥3,042,000 (Direct Cost: ¥2,340,000、Indirect Cost: ¥702,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000)
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| Research Abstract |
Drug delivery system(DDS) have enormous potential to improve the efficacy of cancer treatment by chemical modification of drug vehicles. However, limited DDS strategies have been reported with water-soluble drugs, and so far no candidate to reach up to the clinical use. We have developed novel strategy to prepare DDS carrier incorporating water-soluble drug : gemcitabine, and study the potential of this carrier for DDS usage. The contents were the followings.
i) Preparation of gemcitabine incorporated DDS carrier.
ii) Drug release behavior : pH-responsive
iii) in vitro activity of carrier.
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