Research of the mechanisms of progression and metastasis using mouse gastrointestinal cancer models
Project/Area Number |
22800025
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Carcinogenesis
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Research Institution | Kanazawa University |
Principal Investigator |
ISHIKAWA Tomo-o 金沢大学, がん進展制御研究所, 助教 (70322162)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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Keywords | がん / マウスモデル / 炎症 / 転移 / 癌 |
Research Abstract |
To analyze the mechanisms of gastrointestinal cancer progression and metastasis which result in many patient death, tumor cells from mouse genetic models were used to establish a new in vitro system. Tumor cells were isolated from genetic and chemical mouse models for gastric and intestinal tumor formation, cultured and passaged. Transfection of expression vector was also possible in these cells. This system can be utilized for the identification of candidate genes which relate to cancer progression and metastasis.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells2012
Author(s)
Kong D, Piao YS, Yamashita S, Oshima H, Oguma K, Fushida S, Fujimura T, Minamoto T, Seno H, Yamada Y, Satou K, Ushijima T, Ishikawa T, and Oshima M.
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Journal Title
Oncogene
Volume: (in press)
Issue: 35
Pages: 3949-60
DOI
NAID
Related Report
Peer Reviewed
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