| Budget Amount *help |
¥2,743,000 (Direct Cost: ¥2,110,000、Indirect Cost: ¥633,000)
Fiscal Year 2011: ¥1,105,000 (Direct Cost: ¥850,000、Indirect Cost: ¥255,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Research Abstract |
Use-dependent plasticity is a neurophysiological basis of functional recovery by neuro-rehabilitation. In chronic stroke patients, spasticity was often shown in flexors muscles of the paretic upper limbs. In these patients, if use-dependent plasticity can be specifically induced in the extensors muscles, which are antagonists of flexors muscles, functional recovery might be possible. We performed'Hybrid Rehabilitation' consisting of extensors movement training of the paretic upper limbs, and high frequency(5 Hz) repetitive transcranial magnetic stimulation over the affected primary motor area(M1). As a result, use-dependent plasticity was induced in the affected M1 for extensors muscles of upper limbs, and the upper-limb function was recovered in the long term(Koganemaru et al., 2010). Furthermore, we performed fMRI evaluation before and after'Hybrid rehabilitation' and two weeks afterward in 11 chronic stroke patients. As a result, as compared with the pre-intervention, the activation of the affected side SMC, and the bilateral premotor area was reduced during expansion movement of the paralysis side upper limbs in the post-intervention. It suggests that the efficiency of the specific neuronal networks improved, resulting in the recovery of a paretic upper-limbs function by
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