Functional recovery induced by use-dependent plasticity in stroke hemiparesis
| Project/Area Number |
22800038
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,743,000 (Direct Cost: ¥2,110,000、Indirect Cost: ¥633,000)
Fiscal Year 2011: ¥1,105,000 (Direct Cost: ¥850,000、Indirect Cost: ¥255,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Keywords | 使用依存的可塑性 / 脳卒中 / 経頭蓋磁気刺激 / 一次運動野 / リハビリテーション / Use-dependent plasticity / fMRI / TMS / 運動関連野 / 使用依存性可塑性 / 機能的MRI / 経頭蓋磁気刺激装置 / 慢性期脳卒中片麻痺 |
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| Research Abstract |
Use-dependent plasticity is a neurophysiological basis of functional recovery by neuro-rehabilitation. In chronic stroke patients, spasticity was often shown in flexors muscles of the paretic upper limbs. In these patients, if use-dependent plasticity can be specifically induced in the extensors muscles, which are antagonists of flexors muscles, functional recovery might be possible. We performed'Hybrid Rehabilitation' consisting of extensors movement training of the paretic upper limbs, and high frequency(5 Hz) repetitive transcranial magnetic stimulation over the affected primary motor area(M1). As a result, use-dependent plasticity was induced in the affected M1 for extensors muscles of upper limbs, and the upper-limb function was recovered in the long term(Koganemaru et al., 2010). Furthermore, we performed fMRI evaluation before and after'Hybrid rehabilitation' and two weeks afterward in 11 chronic stroke patients. As a result, as compared with the pre-intervention, the activation of the affected side SMC, and the bilateral premotor area was reduced during expansion movement of the paralysis side upper limbs in the post-intervention. It suggests that the efficiency of the specific neuronal networks improved, resulting in the recovery of a paretic upper-limbs function by
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Recovery of upper-limb function due to enhanced use-dependent plasticity in chronic stroke patients2010
Author(s)
Satoko Koganemaru, Tatsuya Mima, Mohamed Nasreldin Thabit, Tomoko Ikkaku, Kenji Shimada, Madoka Kanematsu, Kazuko Takahashi, Gharib Fawi, Ryosuke Takahashi, Hidenao Fukuyama, Kazuhisa Domen
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Journal Title
Brain
Volume: 133
Pages: 3373-3384
Related Report
Peer Reviewed
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