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The antitumor effects of nerve growth factor on human cancer cells

Research Project

Project/Area Number 22800045
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionOkayama University

Principal Investigator

TAKATORI Shingo  岡山大学, 大学院・医歯薬学総合研究科, 助教 (20368707)

Co-Investigator(Renkei-kenkyūsha) KAWASAKI Hiromu  岡山大学, 大学院・医歯薬学総合研究科, 教授 (60125151)
HASHIKAWA Narumi (HOBARA Narumi)  岡山理科大学, 理学部・臨床生命科学科, 講師 (30511159)
GODA Mitsuhiro  新潟大学, 大学院・医歯学総合研究科, 助教 (40585965)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,081,000 (Direct Cost: ¥2,370,000、Indirect Cost: ¥711,000)
Fiscal Year 2011: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Keywords神経成長・栄養因子 / Nerve growth factor / がん新生血管 / 血管周囲神経 / 抗腫瘍効果
Research Abstract

Our present study demonstrated new findings that NGF markedly suppressed the growth of hepatic tumor cell(HepG2) and fibrosarcoma cell(HT1080) via the indirect effect, probably innervation or maturation of tumor neovasculature.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2011

All Presentation (7 results)

  • [Presentation] 前立腺腫瘍増殖に対する神経成長因子の抑制効果2011

    • Author(s)
      普久原聡子
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Nerve growth factorの抗腫瘍効果とメカニズムの解明2011

    • Author(s)
      高取真吾
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ヒト肝臓がん細胞増殖に対する神経成長因子の抑制作用2011

    • Author(s)
      高取真吾
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Nerve growth factor-induced tumor inhibition involves innervations and maturation of tumor neovasculature2011

    • Author(s)
      Satoko Fukuhara
    • Organizer
      Society for Neuroscience 41th Annual Meeting
    • Place of Presentation
      Washington DC
    • Related Report
      2011 Final Research Report
  • [Presentation] The antineoplastic effects of nerve growth factor in mouse tumor growth2011

    • Author(s)
      Shingo Takatori
    • Organizer
      The 40th Annual Scientific Meeting of The Physiological Society of Thailand
    • Place of Presentation
      Khon Kaen
    • Related Report
      2011 Final Research Report
  • [Presentation] The antineoplastic effects of nerve growth factor in mouse tumor growth2011

    • Author(s)
      Shingo Takatori
    • Organizer
      The 40^<th> Annual Scientific Meeting of The Physiological Society of Thailand
    • Place of Presentation
      Khon Kaen, Thailand
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nerve growth factor-induced tumor inhibition involves innervations and maturation of tumor neovasculature2011

    • Author(s)
      Satoko Fukuhara
    • Organizer
      Society for Neuroscience 41^<th> Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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