The analysis of the differentiation and function of the cells in central nervous system regulated by endoplasmic reticulum stress response.
| Project/Area Number |
22800049
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hiroshima University |
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Principal Investigator |
SAITO Atsushi 広島大学, 大学院・医歯薬学総合研究科, 助教 (30580394)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Keywords | 小胞体ストレス / OASIS / 転写因子 / エピジェネティクス / アストロサイト / 分化・成熟 / 神経細胞 / BBF2H7 |
|---|
| Research Abstract |
We revealed that the differentiation of neural precursor cells into astrocytes or neurons was delayed by OASIS or BBF2H7 deficiency. We tried to identify the target genes of transcription factors OASIS and BBF2H7. Consequently, we identified the direct target genes of OASIS in central nervous system. Further, we revealed that the acceleration of the differentiation of neural precursor cells into astrocytes by the signaling from OASIS mediated the epigenetic regulation which promoted the demethylation of the promoter region of astrocyte-specific marker genes.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Regulation of ER molecular chaperoneprevents bone loss in a murine model for osteoporosis2010
Author(s)
Hino S-I, Kondo S, Yoshinaga K, SaitoA, Murakami T, Kanemoto S, Sekiya H, Chihara K, Aikawa Y, Hara H, Kudo T, Sekimoto T, Funamoto T, Chosa E, Imaizumi K
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Journal Title
Journal of Bone and Mineral Metabolism
Volume: 28
Issue: 2
Pages: 131-138
DOI
Related Report
Peer Reviewed
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