Electrophysiological and neuroanatomical analyses of peripheral nerve transection-induced multiple-innervation of lemniscal fibers in the somatosensory thalamus of mice

• Project/Area Number: 22800063
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: TAKEUCHI Yuichi 東京女子医科大学, 医学部, 助教 (70588384)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,535,000 (Direct Cost: ¥1,950,000、Indirect Cost: ¥585,000); Fiscal Year 2011: ¥1,001,000 (Direct Cost: ¥770,000、Indirect Cost: ¥231,000); Fiscal Year 2010: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000)
• Keywords: 神経損傷 / 視床 / シナプス

Research Abstract

Relay neurons in the somatosensory thalamus of mice receive unusual multiple lemniscal fiber innervations after peripheral nerve transection ; however the origin and wiring of the new lemniscal fibers were unknown. In this study, I found electrophysiological and anatomical evidence for ectopic collaterals of lemniscal fibers innervating neighbor relay neurons after the injury. The rewiring found in this study may be a neural basis for changes in receptive fields in the thalamus or phantom sensations after deafferentations.

Research Products

• [Journal Article] Rewiring of afferent fibers in the somatosensory thalamus of mice caused by peripheral sensory nerve transection (2012)
  • Author(s): Takeuchi Y., Yamasaki M., Nagumo Y., Imoto K., Watanabe M., and Miyata M
  • Journal Title: The Journal of Neuroscience Volume: (in press)
  • Peer Reviewed
• [Journal Article] 身体地図のリモデリング (2012)
  • Author(s): 宮田麻理子、竹内雄一
  • Journal Title: Clinical Neuroscience誌 Volume: 29巻 Pages: 895-899
• [Journal Article] Rewiring of afferent fibers in the somatosensory thalamus of mice caused by peripheral sensory nerve transection (2012)
  • Author(s): Takeuchi Y., et al
  • Journal Title: The journal of neuroscience Volume: (in press)
  • Peer Reviewed
• [Journal Article] 身体地図のリモデリング (2011)
  • Author(s): 宮田麻理子、竹内雄一
  • Journal Title: Clinical Neuroscience Volume: 29 Pages: 895-899
• [Presentation] Peripheral sensory nerve transection-induced remodeling of afferent synapses in the somatosensory thalamus of mice (2011)
  • Author(s): Miyata M. et al
  • Organizer: 8th IBRO World Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-18
• [Presentation] Transection of the infraorbital nerve induces rewiring of afferent fibers in the somatosensory thalamus of mice (2010)
  • Author(s): Takeuchi Y. et al
  • Organizer: 第40回北米神経科学学会年会
  • Place of Presentation: San Diego, U. S. A
  • Year and Date: 2010-11-15
• [Presentation] Transection of the infraorbital nerve induces rewiring of afferent fibers in the somatosensory thalamus of mice (2010)
  • Author(s): 竹内雄一
  • Organizer: 北米神経科学学会
  • Place of Presentation: サンディエゴコンベンションセンター(San Diego, U.S.A)
  • Year and Date: 2010-11-15
• [Presentation] 末梢感覚神経切断は体性感覚視床における求心性シナプスの再編成を誘導する (2010)
  • Author(s): 竹内雄一
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] 末梢感覚神経切断は体性感覚視床における求心性シナプスの再編成を誘導する (2010)
  • Author(s): 竹内雄一
  • Organizer: 日本神経科学学会
  • Place of Presentation: 神戸コンペンションセンター(神戸)
  • Year and Date: 2010-09-04
• [Remarks]
  • URL: http://www.twmu.ac.jp/Basic/physiol1/
• [Remarks]
  • URL: http://www.twmu.ac.jp/Basic/physiol1/index.html
• [Remarks]
  • URL: http://www.twmu.ac.jp/Basic/physiol1/index.html