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Association of Vitamin D status with upper respiratory tract infection and all-cause mortality in the Japanese institutionalized elderly

Research Project

Project/Area Number 22800072
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionOsaka Shoin Women's University

Principal Investigator

KUWABARA Akiko  大阪樟蔭女子大学, 学芸学部・健康栄養学科, 講師 (00582602)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,938,000 (Direct Cost: ¥2,260,000、Indirect Cost: ¥678,000)
Fiscal Year 2011: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000)
Fiscal Year 2010: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000)
Keywords栄養学 / 臨床 / 施設入居高齢者 / ビタミンD / 上気道感染症 / 死亡 / 施設入所高齢者
Research Abstract

We have performed a prospective 2-year cohort study for 208 Japanese institutionalized elderly to study the risk factors for all-cause mortality and upper tract respiratory infection with emphasis on serum vitamin D level and BMI. Vitamin D deficiency(25OHD<10ng/mL) was associated with increased infection, although not statistically significant by Kaplan. Meier plots(log-rank test ; p=0.20). Serum vitamin D level was not significantly associated with all-cause mortality or upper respiratory tract infection by Cox regression analyses. BMI was a significant predictor for all-cause mortality(HR, 0.86, 95% CI ; 0.76-0.97) by Cox regression analyses. BMI. 20.3 kg/m2 was associated with significantly increased risk of mortality.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (19 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (9 results)

  • [Journal Article] Body weight divided by squared knee height as an alternative to body mass index2011

    • Author(s)
      Kuwabara A, Ogawa-Shimokawa Y, Tanaka K
    • Journal Title

      Med Hypotheses

      Volume: 73 Pages: 336-338

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone is more susceptible to vitamin K deficiency than liver in the institutionalized elderly2011

    • Author(s)
      Kuwabara A, Fujii M, Kawai N, Tozawa K, Kido S, Tanaka K
    • Journal Title

      Asia Pac J Clin Nutr

      Volume: 20 Pages: 50-55

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of hypovitaminosis D and K in patients with hip fracture2011

    • Author(s)
      Nakano T, Tsugawa N, Kuwabara A, Kamao M, Tanaka K, Okano T
    • Journal Title

      Asia Pac J Clin Nutr

      Volume: 20 Pages: 56-61

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overestimated serum albumin levels in patients with hip fracture2011

    • Author(s)
      Nakano T, Kuwabara A, Tanaka K
    • Journal Title

      Clin Nutr

      Volume: 30 Pages: 261-261

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 日本人の食事摂取基準における目安量は健康人の摂取の中央値でよいのか?2011

    • Author(s)
      田中清, 桑原晶子
    • Journal Title

      ビタミン

      Volume: 85 Pages: 608-609

    • NAID

      110008762055

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 栄養とビタミンD2011

    • Author(s)
      桑原晶子, 田中清
    • Journal Title

      THE BONE

      Volume: 25 Pages: 271-275

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Overestimated serum albumin levels in patients with hip fracture2011

    • Author(s)
      Nakano T, Kuwabara A, 他
    • Journal Title

      Clinical Nutrition

      Volume: 30 Pages: 261-261

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone is more susceptible to vitamin K deficiency than liver in the institutionalized elderly.2011

    • Author(s)
      Kuwabara Akiko, et al.
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: 20 Pages: 50-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Prevalence of Hypovitaminosis D and K in Patients with Hip Fracture.2011

    • Author(s)
      Nakano Tetsuo, et al.
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: 20 Pages: 56-61

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Body Weight Divided by Squared Knee Height as an Alternative to Body Mass Index2010

    • Author(s)
      Kuwabara Akiko, et al.
    • Journal Title

      Medical Hypotheses

      Volume: 76 Pages: 336-338

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高齢者の栄養アセスメントにおける身長低下、身長/膝高比の意義2012

    • Author(s)
      桑原晶子、楊鴻生, 他
    • Organizer
      日本病態栄養学会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2012-01-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 施設入居高齢者コホートにおけるビタミンD栄養状態と転倒・骨折との関連性の検討2011

    • Author(s)
      桑原晶子、田中清, 他
    • Organizer
      日本骨粗鬆症学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] The impact of vitamin K therapy on bone metabolic markers in severe motor and intellectual disabilities2011

    • Author(s)
      Kuwabara A, Tanaka K, 他
    • Organizer
      American Society for Bone and Mineral Research 33rd Annual Meeting
    • Place of Presentation
      米国サンディエゴ市
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高齢者における歯の残存数と栄養状態との関連性の検討2011

    • Author(s)
      桑原晶子、田中清, 他
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高齢者におけるビタミンDレベルの実態2011

    • Author(s)
      桑原晶子
    • Organizer
      神奈川骨粗鬆症治療フォーラム
    • Place of Presentation
      横浜ベイシェラトンホテル&タワーズ
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血中遊離トリヨードサイロニン(FT3)値の栄養指標としての検討2011

    • Author(s)
      桑原晶子、田中清, 他
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高齢者におけるビタミンDレベルの実態2011

    • Author(s)
      桑原晶子
    • Organizer
      第13回神奈川骨粗鬆症治療フォーラム(招待講演)
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨の健康とビタミン-食事摂取基準2015年にむけて-高齢者におけるビタミンD・K栄養状態について2010

    • Author(s)
      桑原晶子
    • Organizer
      日本栄養改善学会
    • Place of Presentation
      女子栄養大学
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨の健康とビタミン-食事摂取基準2015年にむけて-高齢者におけるビタミンD・K栄養状態について2010

    • Author(s)
      桑原晶子
    • Organizer
      第57回日本栄養改善学会学術総会(シンポジウム)
    • Related Report
      2011 Final Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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