Comprehensive analysis of epigenetic dynamics during the peri-implantation period in mouse
| Project/Area Number |
22800084
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MATOBA Shogo 独立行政法人理化学研究所, 遺伝工学基盤技術室, 基礎科学特別研究員 (20585202)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Keywords | 着床 / エピジェネティクス / リプログラミング / ヒストン修飾 / 体細胞クローン / 核移植クローン / 胚体外領域 / エピブラスト |
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| Research Abstract |
Implantation is critical for the embryonic development in mammals. This study aimed to understand the dynamic change of the epigenetic status during implantation. Analyses of histone modifications and global gene expression in mouse pre-and post-implantation embryos successfully revealed the epigenetic dynamics during implantation. Specifically, we found that H3K9me2, suppressive histone modification, dramatically decreases during implantation and this decrease seems to normalize the epigenetic abnormities in cloned mice generated by somatic cell nuclear transfer.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos2011
Author(s)
Matoba S, Inoue K, Kohda T, Sugimioto M, Mizutani E, Ogonuki N, Nakamura T, Abe K, Nakano T, Ishino F, Ogura A
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Pages: 20621-20626
Related Report
Peer Reviewed
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[Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer2010
Author(s)
Inoue K, Kohda T, Sugimoto M, Sado T, Ogonuki N, Matoba S, Shiura H, Ikeda R, Mochida K, Fujii T, Sawai K, Otte AP, Tian XC, Yang X, Ishino F, Abe K, Ogura A
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Journal Title
Science
Volume: 330
Pages: 496-499
Related Report
Peer Reviewed
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[Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.2010
Author(s)
Inoue K, Kohda T, Sugimoto M, Sado T, Ogonuki N, Matoba S, Shiura H, Ikeda R, Mochida K, Fujii T, Sawai K, Otte AP, Tian XC, Yang X, Ishino F, Abe K, Ogura A.
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Journal Title
Science
Volume: 330
Pages: 496-499
Related Report
Peer Reviewed
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