| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
Fiscal Year 2010: ¥1,625,000 (Direct Cost: ¥1,250,000、Indirect Cost: ¥375,000)
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| Research Abstract |
A series of conjugates of abasic site-binding ligands with fluorescent signaling intercalators have been synthesized with a view toward gene analysis, especially single nucleotide polymorphisms (SNPs). With focusing on the variability of the emission wavelength of DNA-binding cyanine dyes by modification of their structures, blue, green, red fluorescence signaling conjugates have been developed for the selective detection of pyrimidine nucleobase over purine nucleobases.
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