Facile Synthesis of Glycoconjugate based on Direct Synthesis of Glycosyl Azide in Water
| Project/Area Number |
22850010
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
TANAKA Tomonari 京都工芸繊維大学, 工芸科学研究科, 助教 (70585695)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2011: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
Fiscal Year 2010: ¥1,625,000 (Direct Cost: ¥1,250,000、Indirect Cost: ¥375,000)
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| Keywords | 糖鎖高分子 / オリゴ糖 / クリックケミストリー / 無保護 / 脱水縮合剤 / 直接活性化 |
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| Research Abstract |
It is very difficult to prepare glycoconjugates with oligosaccharide by chemical synthesis because it necessitates laborious tasks including protection and deprotection of hydroxy groups. Then, the facile method of glycoconjugates with oligosaccharide is demanded. In this research, I successfully developed the protecting-group-free addition of oligosaccharide by direct azidation of unprotected sugar and Click chemistry starting from unprotected sugar.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Crystal Structures of Glycoside Hydrolase Family 51 α-L-Arabinofuranosidase from Thermotoga maritima2012
Author(s)
Do-Hyun Im, Kei-ichi Kimura, Fumitaka Hayasaka, Tomonari Tanaka, Masato Noguchi, Atsushi Kobayashi, Shin-ichiro Shoda, Kentaro Miyazaki, Takayoshi Wakagi, Shinya Fushinobu
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 76
Issue: 2
Pages: 423-428
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] 4, 6-Dimethoxy-1, 3, 5-triazin-2-ylυ-D-glycosaminides : Novel Substrates for Transglycosylation Reaction Catalyzed by Exo-υ-D-glucosaminidase from Amycolatopsis orientalis
Author(s)
Tomonari Tanaka, Tomonori Wada, Masato Noguchi, Masaki Ishihara, Atsushi Kobayashi, Takayuki Ohnuma, Tamo Fukamizo, Ryszard Brzezinski, Shin-ichiro Shoda
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Journal Title
J. Carbohydr. Chem
Volume: (in press)
Related Report
Peer Reviewed
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