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Mechanical Impedance Sensing of Single Microorganism by Microtool

Research Project

Project/Area Number 22860030
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionNagoya University

Principal Investigator

KAWAHARA Tomohiro  名古屋大学, 工学研究科, COE特任助教 (20575162)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Keywordsマイクロマシン / 微生物 / 計測工学生物・生体工学 / 計測工学 / 生物・生体工学
Research Abstract

In this research, we newly propose an untethered type of magnetically driven microtool(MMT) with a force sensing function to investigate the stimulus characteristics of aquatic microorganisms in a microfluidic chip. The microchip is composed of the proposed MMTs, a transparent cover, a glass substrate, and a microspacer. Finally, we succeeded in on-chip manipulation and sensing of microorganisms(Pleurosira laevis) using this MMT, which we found to be easy to use.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (23 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 磁気駆動マイクロツールによる珪藻のオンチップ刺激特性評価2011

    • Author(s)
      川原知洋, 杉田真邦, 萩原将也, 山西陽子, 新井史人, 河野弘幸, 石川依久子, 宮脇敦史
    • Journal Title

      日本ロボット学会誌

      Volume: Vol.29, No.7 Pages: 650-657

    • NAID

      10029514032

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-Chip Particle Sorting into Multiple Channels by Magnetically Driven Microtools2011

    • Author(s)
      M. Hagiwara, M. Niimi, T. Kawahara, Y. Ymanishi, H. Nakanishi, and F. Arai
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: Vol.23, No.3 Pages: 370-377

    • NAID

      110009957745

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Precise Control of Magnetically Driven Microtools for Enucleation of Oocytes in a Microfluidic Chip2011

    • Author(s)
      M. Hagiwara, T. Kawahara, Y. Yamanishi, and F. Arai
    • Journal Title

      Advanced Robotics

      Volume: Vol.25 Issue: 8 Pages: 991-1005

    • DOI

      10.1163/016918611x568611

    • NAID

      10029513375

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-Chip Magnetically Actuated Robot with Ultrasonic Vibration for Single Cell Manipulations2011

    • Author(s)
      M.Hagiwara, T.Kawahara, Y.Yamanishi, T.Masuda, L.Feng, F.Arai
    • Journal Title

      Lab on a Chip

      Volume: 11 Issue: 12 Pages: 2049-2054

    • DOI

      10.1039/c1lc20164f

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Driving Method of Microtool by Horizontally-arranged Permanent Magnets for Single Cell Manipulation2011

    • Author(s)
      M. Hagiwara, T. Kawahara, Y. Yamanishi, and F. Arai
    • Journal Title

      Applied Physics Letters

      Volume: Vol.97

    • URL

      http://dx.doi.org/10.1063/1.3459040

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-Chip Magnetically Actuated Robot with Ultrasonic Vibration for Single Cell Manipulations2011

    • Author(s)
      M.Hagiwara, T.Kawahara, et al
    • Journal Title

      Lab on a Chip

      Volume: 11 Pages: 2049-2054

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precise Control of Magnetically Driven Microtools for Enucleation of Oocytes in a Microfluidic Chip2011

    • Author(s)
      M.Hagiwara, T.Kawahara, et al
    • Journal Title

      Advanced Robotics

      Volume: 25 Pages: 991-1005

    • NAID

      10029513375

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On-Chip Particle Sorting into Multiple Channels by Magnetically Driven Microtools2011

    • Author(s)
      M.Hagiwara, T.Kawahara, et al
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: 23(3) Pages: 370-377

    • NAID

      110009957745

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 磁気駆動マイクロツールによる珪藻のオンチップ刺激特性評価2011

    • Author(s)
      川原知洋, ほか
    • Journal Title

      日本ロボット学会誌

      Volume: 29(7) Pages: 650-657

    • NAID

      10029514032

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Precise Control of Magnetically Driven Microtools for Enucleation of Oocytes in a Microfluidic Chip2011

    • Author(s)
      M.Hagiwara, T.Kawahara, et al.
    • Journal Title

      Advanced Robotics

      Volume: 印刷中(未定)

    • NAID

      10029513375

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2DOF Magnetically Driven Microtool for Soft Peeling of Zona Pellucida2010

    • Author(s)
      Y. Yamanishi, T. Kawahara, T. Iyanagi, M. Hagiwara, T. Mizunuma, N. Inomata, S. Kudo, and F. Arai
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: Vol.22, No.5 Pages: 623-630

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Driving Method of Microtool by Horizontally-arranged Permanent Magnets for Single Cell Manipulation2010

    • Author(s)
      M.Hagiwara, T.Kawahara, et al.
    • Journal Title

      Applied Physics Letters

      Volume: 97-013701 Pages: 1-3

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2DOF Magneticaly Driven Microtool for Soft Peeling of Zona Penucida2010

    • Author(s)
      Y.Yamanishi, T.Kawahara, et al
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: 22-5 Pages: 623-630

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] On-Chip Manipulation and Sensing of Microorganisms by Magnetically Driven Microtools with Force Sensing Structure2012

    • Author(s)
      T. Kawahara, M. Sugita, M. Hagiwara, Y. Yamanishi, F. Arai, H. Kawano, I. Shihira-Ishikawa, and A. Miyawaki
    • Organizer
      IEEE Int. Conf. on Robotics and Automation
    • Place of Presentation
      St. Paul(USA)
    • Year and Date
      2012-05-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Robotic-Investigators for Microorganisms in a Microfluidic Chip2012

    • Author(s)
      M. Sugita, T. Kawahara, M. Hagiwara, Y. Yamanishi, and F. Arai
    • Organizer
      25th IEEE Int. Conf. on Micro Electro Mechanical Systems
    • Place of Presentation
      Paris(France)
    • Year and Date
      2012-02-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Robotic-Investigators for Microorganisms in a Microfluidic Chip2012

    • Author(s)
      M.Sugita, T.Kawahara, et al
    • Organizer
      25th IEEE International Conference on Micro Electro Mechanical Systems
    • Place of Presentation
      Paris (France)
    • Year and Date
      2012-02-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Control and Sensing Platform of Magnetically driven Microtool for On-Chip Single Cell Evaluation2011

    • Author(s)
      T. Kawahara, M. Hagiwara, Y. Yamanishi, and F. Arai
    • Organizer
      I IEEE Int. Symp. on Micro-Nano Mechatronics and Human Scien
    • Place of Presentation
      Noyori Conference Hall(Japan)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 3DOF Dual-Arm Microrobots Enabling Force Sensing in a Microfluidic Chip2011

    • Author(s)
      M.Sugita, T.Kawahara, et al
    • Organizer
      IEEE International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Nagoya (Japan)
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ultra-High-Speed Robot Hand and Eye for Investigation of Microorganisms in a Chip2011

    • Author(s)
      T. Kawahara, M. Sugita, M. Hagiwara, Y. Yamanishi, and F. Arai
    • Organizer
      15th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Seattle(USA)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Ultra-High-Speed Robot Hand and Eye for Investigation of Microorganisms in a Chip2011

    • Author(s)
      T.Kawahara, et al
    • Organizer
      15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Seattle (USA)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] オンチップ微生物操作・計測のための3自由度双腕磁気駆動マイクロツール2011

    • Author(s)
      杉田真邦, 川原知洋, ほか
    • Organizer
      第29回日本ロボット学会学術講演会
    • Place of Presentation
      芝浦工業大学豊洲キャンパス(東京都)
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 微生物の生態・機能解析に向けたオンチップビオトープ2011

    • Author(s)
      杉田真邦, 川原知洋, ほか
    • Organizer
      第23回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      千葉大学西千葉キャンパス(千葉県)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Micro-Aquatic-Farm : On-Chip Stimulation and Evaluation System for Microorganisms by Magnetically Driven Microtools2011

    • Author(s)
      T. Kawahara, M. Sugita, M. Hagiwara, Y. Yamanishi, F. Arai, H. Kawano, I. Shihira-Ishikawa, and A. Miyawaki
    • Organizer
      16th Int. Conf. on Solid-State Sensors, Actuators and Microsystems
    • Place of Presentation
      Beijing(China)
    • Year and Date
      2011-06-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Micro-Aquatic-Farm : On-Chip Stimulation and Evaluation System for Microorganisms by Magnetically Driven Microtools2011

    • Author(s)
      T.Kawahara, et al
    • Organizer
      16th International Conference on Solid-State Sensors, Actuators and Microsystems
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] オンチップビオトープ-マイクロロボットによる珪藻の力学的刺激応答計測-2011

    • Author(s)
      川原知洋,杉田真邦,萩原将也,山西陽子,新井史人,河野弘幸,石川依久子,宮脇敦史
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 超高速オンチップロボットPart I-単一細胞操作を行う磁気駆動マイクロツールのための超高速計測制御-2011

    • Author(s)
      川原知洋,萩原将也,山西陽子,新井史人
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] On-Chip Force Sensing by Magnetically Driven Microtool for Measurement of Stimulant Property of P. laevis2011

    • Author(s)
      T. Kawahara, M. Sugita, M. Hagiwara, Y. Yamanishi, F. Arai, H. Kawano, I. Shihira-Ishikawa, and A. Miyawaki
    • Organizer
      IEEE Int. Conf. on Robotics and Automation
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2011-05-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Force Sensing by Magnetically Driven Microtool for Measurement of Stimulant Property of P.laevis2011

    • Author(s)
      T.Kawahara, et al
    • Organizer
      IEEE International Conference on Robotics and Automation
    • Place of Presentation
      Shanghai (China)
    • Year and Date
      2011-05-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] On-Chip Force Sensing by Magnetically Driven Microtool for Measurement of Stimulant Property of P.laevis2011

    • Author(s)
      T.Kawahara, et al.
    • Organizer
      IEEE International Conference on Robotics and Automation(発表確定)
    • Place of Presentation
      International Conference Center (Shanghai)
    • Year and Date
      2011-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stimulus Response Measurement of Microorganisms by Magnetically Driven Microtool in a Microfluidic Chip2011

    • Author(s)
      T. Kawahara, M. Hagiwara, Y. Yamanishi, and F. Arai
    • Organizer
      Nano-Biomedicine Symposium
    • Place of Presentation
      Noyori Conference Hall(Japan)
    • Year and Date
      2011-02-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Stimulus Response Measurement of Microorganisms by Magnetically Driven Microtool in a Microfluidic Chip2011

    • Author(s)
      T.Kawahara, et al.
    • Organizer
      Nano-Biomedicine Symposium
    • Place of Presentation
      Noyori Conference Hall, Nagoya University (Nagoya)
    • Year and Date
      2011-02-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] On-Chip Stimulation and Evaluation System for Microorganisms by Magnetically Driven Microtools2011

    • Author(s)
      T.Kawahara, et al.
    • Organizer
      16th International Conference on Solid-State Sensors, Actuators and Microsystems(発表確定)
    • Place of Presentation
      China National Convention Center (Beijing)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁気駆動マイクロツールを用いた細胞のオンチップ硬さ計測2010

    • Author(s)
      杉田真邦, 川原知洋, ほか
    • Organizer
      第11回計測自動制御学会システムインテグレーション部門講演会
    • Place of Presentation
      東北大学川内キャンパス(宮城県)
    • Year and Date
      2010-12-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] オンチップ力計測機能を有する磁気駆動マイクロツール2010

    • Author(s)
      川原知洋,杉田真邦,萩原将也,山西陽子,新井史人,河野弘幸,石川依久子,宮脇敦史
    • Organizer
      第22回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      名古屋大学医学部附属病院(愛知県)
    • Year and Date
      2010-11-17
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Control and Sensing Platform of Magnetically driven Microtool for On-Chip Single Cell Evaluation2010

    • Author(s)
      T.Kawahara, et al.
    • Organizer
      IEEE International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Noyori Conference Hall, Nagoya University (Nagoya)
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁気駆動マイクロツールの高精度位置決め制御と珪藻の刺激特性計測への応用2010

    • Author(s)
      川原知洋,杉田真邦,萩原将也,山西陽子,新井史人,河野弘幸,石川依久子,宮脇敦史
    • Organizer
      第28回日本ロボット学会学術講演会
    • Place of Presentation
      名古屋工業大学(愛知県)
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] ロボコンマガジン:高速で精密な細胞操作を実現するマイクロロボット~磁気駆動オンチップマイクロロボットの開発とその応用2012

    • Author(s)
      川原知洋
    • Publisher
      オーム社
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.lsse.kyutech.ac.jp/~kawahara

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/member/profile/Kawahara.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.biorobotics.mech.nagoya-u.ac.jp/member/profile/Kawahara.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] マイクロ流体チップ内における磁気駆動マイクロツールの駆動機構2011

    • Inventor(s)
      新井史人,萩原将也,川原知洋,山西陽子
    • Industrial Property Rights Holder
      新井史人,萩原将也,川原知洋,山西陽子
    • Filing Date
      2011-11-04
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] マイクロ流体チップ内における磁気駆動マイクロツールの駆動機構2010

    • Inventor(s)
      新井史人, 川原知洋, ほか
    • Industrial Property Rights Holder
      名古屋大学
    • Filing Date
      2010-05-11
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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