| Project/Area Number |
22870007
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HAYASHI Yohei The University of Tokyo, 分子細胞生物学研究所, 博士研究員 (00588056)
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| Project Period (FY) |
2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Keywords | エピジェネティクス / 複雑ネットワーク / 蛋白質 / 化学修飾 / 頑強性 / ヒストン |
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| Research Abstract |
Our previous theory on histone modifications suggested that mutual controls among a wide variety of histone modifications form complex histone modification network. In this study, to elucidate how the network is built and working in iving cells, the aberrances of the network caused by the point mutation of histone modifiable residues were comprehensively examined as phenotypic changes using the histone point-mutant library of the budding yeast. As a result, histone H3-Lys4, -Lys36 and histone H4-Lys12, -Lys16 were identified as modifiable residues working as "functional hubs", which play an important role in the maintenance of biological functions.
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