Biological function of novel adrenomedullin in vertebrates : a reverse-phylogenic approach

• Project/Area Number: 22870020
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Morphology/Structure
• Research Institution: Okayama University
• Principal Investigator: OGOSHI Maho 岡山大学, 大学院・自然科学研究科, 助教 (00527997)
• Co-Investigator(Renkei-kenkyūsha): SAKAMOTO Tatsuya 岡山大学, 大学院・自然科学研究科, 教授 (10294480)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: アドレノメデュリン / 脊椎動物 / 比較内分泌学

Research Abstract

We have clarified that all five members of adrenomedullin(AM) family were expressed in tissues of medaka(Oryzias latipes) including osmoregulatory organs. The expressions of AM1, AM3, AM4 and AM5 were increased after transfer to freshwater and decreased in seawater, whereas that of AM2 was increased in seawater. The obtained data suggest that AM family genes except for AM2 are involved in freshwater adaptation, whereas AM2 is related to the adaptation to seawater.

Research Products

• [Journal Article] Growth, energetics and the cortisol-hepatic glucocorticoid receptor axis of medaka(Oryzias latipes) in various salinities (2012)
  • Author(s): Maho Ogoshi, Kanoko Kato, Hideya Takahashi, Toshitaka Ikeuchi, Tsukasa Abe, Tatsuya Sakamoto
  • Journal Title: Oryzias latipes Volume: (in press)
  • Peer Reviewed
• [Journal Article] O_2-filled swimbladder employs monocarboxylate transporters for the generation of O_2 by lactate-induced Root effect hemoglobin (2012)
  • Author(s): Umezawa T, Kato A, Ogoshi M, Ookata K, Doi H, Romero MF, Hirose S
  • Journal Title: PLoS ONE Volume: 7 Issue: 4 Pages: e34579-e34579
  • DOI: 10.1371/journal.pone.0034579
  • Peer Reviewed
• [Journal Article] Cloning of two members of the calcitonin receptor family from stingray, Dasyatis akajei : Possible physiological roles of the calcitonin family in osmoregulation (2012)
  • Author(s): Suzuki N, Sekiguchi T, Satake H, Kato K, Nishiyama Y, Takahashi H, Danks JA, Martin J, Hattori A, Nakano M, Kakikawa M, Yamada S, Ogoshi M, Hyodo S, Yamaguchi Y, Chowdhury VS, Hayakawa K, Funahashi H, Sakamoto T, Sasayama Y
  • Journal Title: GENE Volume: (印刷中)(発行中)
  • Peer Reviewed
• [Journal Article] Corticosteroids stimulate the amphibious behavior in mudskipper : Potential role of mineralocorticoid receptors in teleost fish (2011)
  • Author(s): Sakamoto T, Mori C, Minami S, Takahashi H, et al
  • Journal Title: Physiology & Behavior Volume: 104 Issue: 5 Pages: 923-928
  • DOI: 10.1016/j.physbeh.2011.06.002
  • Peer Reviewed
• [Journal Article] Rapid signaling of steroid hormones in the vertebrate nervous system : a comparative insight from fish to mammals (2011)
  • Author(s): Sakamoto H, Takahashi H, Matsuda K, Nishi M, Takanami K, Ogoshi M, Sakamoto T, Kawata M
  • Journal Title: Frontiers in Bioscience Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Differential expression of Na+-Cl- cotransporter and Na^+-K^+-Cl^- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes (2010)
  • Author(s): Kato A, Muro T, Kimura Y, Li S, Islam Z, Ogoshi M, Doi H, Hirose S
  • Journal Title: American Journal of Physiology : Regulatory, Integrative and Comparative Physiology Volume: 300
  • Peer Reviewed
• [Presentation] アドレノメデュリンファミリーの機能を魚類から探る (2012)
  • Author(s): 御輿真穂
  • Organizer: 中国四国地区生物系三学会合同大会(島根大会)
  • Place of Presentation: 松江
  • Year and Date: 2012-05-12
• [Presentation] 赤血球の消長におけるアドレノメデュリン遺伝子の発現動態 (2011)
  • Author(s): 御輿真穂
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 旭川
  • Year and Date: 2011-09-21
• [Presentation] メダカ脳におけるアンドロゲン受容体の発現と局在 (2011)
  • Author(s): 秋山美穂、高橋英也、荻野由紀子、宮川信一、御輿真穂、井口泰泉、坂本竜哉、坂本浩隆
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 旭川
• [Presentation] 脊椎動物におけるアドレノメデュリンファミリーの進化と機能 (2010)
  • Author(s): 御輿真穂
  • Organizer: 第35回日本比較内分泌学会及びシンポジウムプレイブニングシンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-18
• [Presentation] Cardiovascular and osmoregulatory effects of homologous adrenomedullins in the eels (2010)
  • Author(s): Maho Ogoshi
  • Organizer: 7th International Symposia on the CGRP Family ; CGRP, Adrenomedullin, Amylin, Intermedin and Calcitonin
  • Place of Presentation: Queenstown, New Zealand
  • Year and Date: 2010-08-29
• [Presentation] Novel adrenomedullins and possible presence of novel receptors in the CGRP family (2010)
  • Author(s): Yoshio Takei, Maho Ogoshi
  • Organizer: 7th International Symposia on the CGRP Family ; CGRP, Adrenomedullin, Amylin, Intermedin and Calcitonin
  • Place of Presentation: Queenstown, New Zealand
• [Presentation] 硬骨魚類アドレノメデュリンファミリーの機能解析 (2010)
  • Author(s): 御興真穂、加藤花野子、野畑重教、竹井祥郎、広瀬茂久、坂本竜哉
  • Organizer: 日本動物学会 第81回大会
  • Place of Presentation: 東京
• [Presentation] 脊椎動物におけるアドレノメデュリンファミリーの進化と機能 (2010)
  • Author(s): 御興真穂
  • Organizer: 第35回日本比較内分泌学会及びシンポジウム プレイブニングシンポジウム
  • Place of Presentation: 静岡
• [Presentation] 硬骨魚類アドレノメデュリンファミリーの機能解析
  • Author(s): 御輿真穂
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京
• [Book] 第2版現代生物学入門 (2011)
  • Author(s): 坂本竜哉, 御輿真穂, 他
  • Publisher: 岡山大学出版
• [Book] 現代生物学入門 第2版 (2011)
  • Author(s): 岡山大学生物学科教科書作成委員会
  • Publisher: 岡山大学出版会