| Project/Area Number |
22880003
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,899,000 (Direct Cost: ¥2,230,000、Indirect Cost: ¥669,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,482,000 (Direct Cost: ¥1,140,000、Indirect Cost: ¥342,000)
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| Keywords | 乳腺 / イオンチャネル / 上皮細胞 / 電気生理学 / 発達 |
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| Research Abstract |
It has been suggested that the selective ion transport of mammary epithelial cells play an important role in lactation. However, active ion channels in mammary secretory cells are unknown. To reveal the mechanisms of lactation, we investigated the active ion channels in mammary secretory cells. A whole-cell patch clamp technique was applied to mammary epithelial cells (MEC) freshly isolated from mammary glands of lactating mice. In this study, we found the functional expression of inwardly rectifying potassium (Kir) channels in lactating MEC.
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