Mechanism of high-density lipoprotein(HDL) formation by ABCA1
| Project/Area Number |
22880016
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied biochemistry
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
NAGAO Kohjiro 京都大学, 物質-細胞統合システム拠点, 研究員 (40587325)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
|
|---|
| Keywords | cholesterol / ABCA1 / HDL |
|---|
| Research Abstract |
ABCA1 mediates the high-density lipoprotein(HDL) formation by loading cellular cholesterol onto apolipoproteinA-I(apoA-I). In this study, we analyzed the interaction between ABCA1 and apoA-I, which is first step of HDL formation. We showed that conformation of extracellular domain of ABCA1 is changed by ATP hydrolysis in nucleotide domain, and apoA-I binding site is produced by this conformation changes.
|
Report
(3 results)
Research Products
(16 results)
-
[Journal Article] ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding.2012
Author(s)
Nagao, K., Takahashi, K., Azuma, Y., Takada, M., Kimura, Y., Matsuo, M., Kioka, N. and Ueda, K.
-
Journal Title
J Lipid Res
Volume: 53
Issue: 1
Pages: 126-136
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
