The mechanisms of DNA demethylation by APOBEC2 deaminase during myogenic differentiation
| Project/Area Number |
22880025
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Kyushu University |
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Principal Investigator |
SATO Yusuke 九州大学, 農学研究院, 特任助教 (50589520)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,964,000 (Direct Cost: ¥2,280,000、Indirect Cost: ¥684,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000)
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| Keywords | 骨格筋 / APOBEC2 / 筋分化 / 筋再生 / DNA脱メチル化 / 筋文化 |
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| Research Abstract |
The aim of the present research was to understand the mechanisms of skeletal muscle growth and hypertrophy. We hypothesized that the myogenic differentiation was regulated by DNA demethylation via deamination by APOBEC2 enzyme. As a result, we found that lack of APOBEC2 promoted the myogenic differentiation. APOBEC2 might negatively regulate muscle differentiation.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Growth factor regulation of neural chemorepellent Sema3A expression in satellite cell cultures2011
Author(s)
Do, M.-K. Q., Sato, Y., Shimizu, N., Suzuki, T., Shono, J.-I., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Anderson, J. E., and Tatsumi, R
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Journal Title
American Journal of Physiology-Cell Physiology
Volume: 301
Issue: 5
Pages: C1270-C1279
DOI
Related Report
Peer Reviewed
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[Presentation] 筋衛星細胞の活性化における物理刺激受容機構の解明2011
Author(s)
原美菜子, 田畑久仁子, 真鍋宣隆, 佐藤祐介, 水野谷航, 中村真子, 辰巳隆一, 西村正太郎, 田畑正志, 池内義秀
Organizer
第114回日本畜産学会大会
Place of Presentation
北里大学獣医学部十和田キャンパス(十和田市)
Year and Date
2011-08-26
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[Presentation] FASEB Summer Research Conference onSkeletal Muscle Satellite & Stem Cells2010
Author(s)
Sate Y, Probst HC, Mizunoya W, Tatsumi R, Rada C, Neuberger MS, and Ikeuchi Y
Organizer
Skeletal Muscle Fiber-Type Change, Diminished Body Mass and Myopathy in APOBEC2 KO Mouse
Place of Presentation
Carefree Resort, Carefree, AZ, US
Related Report
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[Presentation] FASEB Summer Research Conference onSkeletal Muscle Satellite & Stem Cells2010
Author(s)
Do MQ, Shimizu N, Sate Y, Suzuki T, Tatsumi R, Mizunoya W, Ikeuchi Y, Anderson JE and Allen RE
Organizer
Possible implication of satellite cells in regenerative motoneuritogenesis : Temporal coordination of HGF/FGF2/TGF-b may regulate neural chemorepellent SemasA expression
Place of Presentation
Carefree Resort, Carefree, AZ, US
Related Report
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[Presentation] on Theme 3 : Tissue Mechanics, Track 3. 6 Muscle Mechanics and Motor Control, the 6th World Congress on Biomechanics 2010, in conjunction with the 14th International Conference on Biomedical Engineering(ICBME) 2010 and the 5th Asian Pacific Conference on2010
Author(s)
Tatsumi R, Do MO, Shimizu N, Sankoda Y, Anderson JE, Sate Y, SuzukiT, Mizunoya W, Ikeuchi Y, and Allen RE
Organizer
Possible implication of satellite cells in regenerative motoneuritogenesis : HGF and FGF2 up regulate neural chemorepellent SemasA expression
Place of Presentation
Suntec Convention and Exhibition Center, Singapore
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