• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The mechanisms of DNA demethylation by APOBEC2 deaminase during myogenic differentiation

Research Project

Project/Area Number 22880025
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Zootechnical science/Grassland science
Research InstitutionKyushu University

Principal Investigator

SATO Yusuke  九州大学, 農学研究院, 特任助教 (50589520)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,964,000 (Direct Cost: ¥2,280,000、Indirect Cost: ¥684,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000)
Keywords骨格筋 / APOBEC2 / 筋分化 / 筋再生 / DNA脱メチル化 / 筋文化
Research Abstract

The aim of the present research was to understand the mechanisms of skeletal muscle growth and hypertrophy. We hypothesized that the myogenic differentiation was regulated by DNA demethylation via deamination by APOBEC2 enzyme. As a result, we found that lack of APOBEC2 promoted the myogenic differentiation. APOBEC2 might negatively regulate muscle differentiation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (27 results)

All 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (22 results) Remarks (3 results)

  • [Journal Article] Growth Factor Regulation of Neural Chemorepellent SemasA Expression in Satellite Cell Cultures2011

    • Author(s)
      Do MK Q, Sateo Y, Shimizu N, Suzuki T, ShenaaIII, Mizunoya W, Nakamura M, Ikeuchi Y, Anderson IE, and Tatsumi R
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: 301

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth factor regulation of neural chemorepellent Sema3A expression in satellite cell cultures2011

    • Author(s)
      Do, M.-K. Q., Sato, Y., Shimizu, N., Suzuki, T., Shono, J.-I., Mizunoya, W., Nakamura, M., Ikeuchi, Y., Anderson, J. E., and Tatsumi, R
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: 301 Issue: 5 Pages: C1270-C1279

    • DOI

      10.1152/ajpcell.00257.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] semaphorin 3Aは筋幹細胞の初期分化を制御する2012

    • Author(s)
      鈴木貴弘, 尾嶋孝一, 佐藤祐介, 中村真子, 水野谷航, 辰巳隆一, 池内義秀
    • Organizer
      第115回日本畜産学会大会
    • Place of Presentation
      名古屋大学東山キャンパス(名古屋市)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] n-3系不飽和脂肪酸による骨格筋線維タイプの変換2012

    • Author(s)
      小宮佑介, 水野谷航, 後藤剛, 高橋信之, 河田照雄, 中村真子, 佐藤祐介, 辰巳隆一, 池内義秀
    • Organizer
      第115回日本畜産学会大会
    • Place of Presentation
      名古屋大学東山キャンパス(名古屋市)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] semaphorin 3Aは筋幹細胞の初期分化を制御する2012

    • Author(s)
      鈴木貴弘,尾嶋孝一,佐藤祐介,中村真子,水野谷航,辰巳隆一,池内義秀
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] n-3系不飽和脂肪酸による骨格筋線維タイプの変換2012

    • Author(s)
      小宮佑介,水野谷航後藤剛,高橋信之,河田照雄,中村真子,佐藤祐介,辰巳隆一,池内義秀
    • Organizer
      日本畜産学会第115回大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 筋衛星細胞の活性化における物理刺激受容機構の解明2011

    • Author(s)
      原美菜子, 田畑久仁子, 真鍋宣隆, 佐藤祐介, 水野谷航, 中村真子, 辰巳隆一, 西村正太郎, 田畑正志, 池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学獣医学部十和田キャンパス(十和田市)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 伸展刺激強度の違いが筋衛星細胞の活性化に及ぼす影響2011

    • Author(s)
      真鍋宣隆, 原美菜子, 佐藤祐介, 水野谷航, 中村真子, 辰巳隆一, 池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学獣医学部十和田キャンパス(十和田市)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 活性化マクロファージは骨格筋再生に関与する2011

    • Author(s)
      生野淳一, 坂口昇平, 佐藤祐介, 水野谷航, 中村真子, 辰巳隆一, 池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学獣医学部十和田キャンパス(十和田市)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大豆イソフラボン摂取がラットの骨格筋線維型に及ぼす影響2011

    • Author(s)
      下材健太, 水野谷航, 中村真子, 佐藤祐介, 辰巳隆一, 池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学獣医学部十和田キャンパス(十和田市)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋特異的脱アミノ化酵素APOBEC2の筋細胞内局在2011

    • Author(s)
      佐藤祐介,大坪秀明,水野谷航,辰巳隆一,池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] TGF一β2, 3は衛星細胞のSemasA発現調節に関与す2011

    • Author(s)
      ド・マイコイ,清水直美,佐藤祐介,水野谷航中村真子,辰巳隆一,池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 筋幹細胞が分泌するsemaphorinsAの生理機能2011

    • Author(s)
      鈴木貴弘尾嶋孝一,佐藤祐介,水野谷航中村真子,辰巳隆一,池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 筋衛星細胞の活性化における物理刺激受容機構の解明2011

    • Author(s)
      原美菜子,田畑久仁子,真鍋宣隆佐藤血,水野谷航,中村真子,辰巳隆一,西村]]三太郎,田畑正志,池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 伸展刺激強度の違いが筋衛星細胞の活性化に及ぼす影響2011

    • Author(s)
      真鍋宣隆,原美菜子,佐藤祐介,水野谷航,中村真子,辰巳隆一,池内義秀
    • Organizer
      第1144回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 活性化マクロファージは骨格筋再生に関与する2011

    • Author(s)
      生野淳一,坂口昇平,佐藤祐介,水野谷航,中村真子,辰巳隆一,池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 大豆イソフラボン摂取がラットの骨格筋線維型に及ぼす影響2011

    • Author(s)
      下村健太,水野谷航,中村真子,佐藤祐介,辰巳隆一,池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 筋特異的脱アミノ化酵素APOBEC2の筋細胞内局在2011

    • Author(s)
      佐藤祐介, 大坪秀明, 水野谷航, 辰巳隆一, 池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス(十和田市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] TGF-β2,3は衛星細胞のSema3A発現調節に関与する2011

    • Author(s)
      ド・マイコイ, 清水直美, 佐藤祐介, 水野谷航, 中村真子, 辰巳隆一, 池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス(十和田市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋幹細胞が分泌するsemaphorin 3Aの生理機能2011

    • Author(s)
      鈴木貴弘, 尾嶋孝一, 佐藤祐介, 水野谷航, 中村真子, 辰巳隆一, 池内義秀
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学十和田キャンパス(十和田市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] FASEB Summer Research Conference onSkeletal Muscle Satellite & Stem Cells2010

    • Author(s)
      Sate Y, Probst HC, Mizunoya W, Tatsumi R, Rada C, Neuberger MS, and Ikeuchi Y
    • Organizer
      Skeletal Muscle Fiber-Type Change, Diminished Body Mass and Myopathy in APOBEC2 KO Mouse
    • Place of Presentation
      Carefree Resort, Carefree, AZ, US
    • Related Report
      2011 Final Research Report
  • [Presentation] FASEB Summer Research Conference onSkeletal Muscle Satellite & Stem Cells2010

    • Author(s)
      Do MQ, Shimizu N, Sate Y, Suzuki T, Tatsumi R, Mizunoya W, Ikeuchi Y, Anderson JE and Allen RE
    • Organizer
      Possible implication of satellite cells in regenerative motoneuritogenesis : Temporal coordination of HGF/FGF2/TGF-b may regulate neural chemorepellent SemasA expression
    • Place of Presentation
      Carefree Resort, Carefree, AZ, US
    • Related Report
      2011 Final Research Report
  • [Presentation] on Theme 3 : Tissue Mechanics, Track 3. 6 Muscle Mechanics and Motor Control, the 6th World Congress on Biomechanics 2010, in conjunction with the 14th International Conference on Biomedical Engineering(ICBME) 2010 and the 5th Asian Pacific Conference on2010

    • Author(s)
      Tatsumi R, Do MO, Shimizu N, Sankoda Y, Anderson JE, Sate Y, SuzukiT, Mizunoya W, Ikeuchi Y, and Allen RE
    • Organizer
      Possible implication of satellite cells in regenerative motoneuritogenesis : HGF and FGF2 up regulate neural chemorepellent SemasA expression
    • Place of Presentation
      Suntec Convention and Exhibition Center, Singapore
    • Related Report
      2011 Final Research Report
  • [Presentation] Skeletal muscle fiber-type change, diminished body mass and myopathy in APOBEC2 KO mouse.2010

    • Author(s)
      佐藤祐介
    • Organizer
      2010 FASEB Summer Research Conference on "Skeletal Muscle Satellite & Stem Cells"
    • Place of Presentation
      Carefree, AZ, US
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://bbsl.agr.kyushu-u.ac.jp/biosci-biotech/chikusan/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://agri.mine.utsunomiya-u.ac.jp/hpj/deptj/anij/item/sato.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://bbs1.agr.kyushu-u.ac.jp/biosci-biotech/chikusan/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-27   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi