Effect of continuous dietary supplementation with EGCG on suppression of postprandial hyperglycemia via regulation of small intestinal function

• Project/Area Number: 22880028
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Chiba Prefectural University of Health Sciences
• Principal Investigator: SHIMADA Masaya 千葉県立保健医療大学, 健康科学部, 助教 (10576755)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: EGCG / α-グルコシダーゼ / GIP / 小腸 / 食後高血糖

Research Abstract

I found that continuously feeding rats a diet containing EGCG reduces GIP protein level as well as alpha-glucosidase activities in the upper small intestine. These suggest that the reductions of the alpha-glucosidase activities and GIP protein level may lead to suppressions of postprandial hyperglycemia and hyperinsulinemia via regulation of small intestinal function.