A role of alphaB-crystallin in angiogenesis of diabetic retinopathy

• Project/Area Number: 22890006
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: KASE Satoru 北海道大学, 北海道大学病院, 医員 (60374394)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: alpha-crystallin / VEGF / 糖尿病網膜症 / 血管新生 / alphaB-crystallin

Research Abstract

AlphaB-crystallin, a small heat shock protein, was expressed in CD31-positive microvessels of proliferative membranes in human diabetic retinopathy, whereas alphaB-crystallin was not expressed in normal retinal vessels, alphaB-crystallin expression was colocalized with VEGF immunoreactivity in proliferative membranes of diabetic retinopathy. Researches on alpha-crystallin toward retinal neovascularization leads to discovery of additional treatments with anti-VEGF therapy, whereby the therapeutic target is not direct VEGF protein itself, but a molecule regulating VEGF degradation.

Research Products

• [Journal Article] AlphaB-crystallin expression in epiretinal membrane of human proliferative diabetic retinopathy (2012)
  • Author(s): Dong Z, Kase S, Ando R, Fukuhara J, Saito W, Kanda A, Murata M, Noda K, Ishida S.
  • Journal Title: Retina[ Epub ahead of print] Volume: (In press) Issue: 6 Pages: 1190-1196
  • DOI: 10.1097/iae.0b013e318233ab9c
  • Peer Reviewed
• [Journal Article] 眼内血管新生の治療標的としてのクリスタリン蛋白 (2012)
  • Author(s): 加瀬諭、坂本泰二、山下英俊
  • Journal Title: あたらしい眼科 Volume: 29(3) Pages: 361-363
  • NAID: 10030547102
  • Peer Reviewed
• [Journal Article] Increased expression ofαA-crystallin in human diabetic eye (2011)
  • Author(s): Kase S, Ishida S, Rao NA.
  • Journal Title: Int J Mol Med Volume: 28(4) Pages: 505-511
  • DOI: 10.3892/ijmm.2011.708
  • Peer Reviewed
• [Journal Article] Immunolocalization of advanced glycation end products in human diabetic eyes (2011)
  • Author(s): Satoru Kase, Susumu Ishida, Narsing Adupa Rao
  • Journal Title: Journal of Diabetes Mellitus Volume: Vol.1, No.3 Issue: 03 Pages: 57-62
  • DOI: 10.4236/jdm.2011.13009
  • ISSN: 2160-5831, 2160-5858
  • Peer Reviewed
• [Journal Article] WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing (2011)
  • Author(s): Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR.
  • Journal Title: Cancer Cell Volume: 20(6) Issue: 6 Pages: 768-80
  • DOI: 10.1016/j.ccr.2011.10.016
  • Peer Reviewed
• [Journal Article] alphaB-crystallin regulation of angiogenesis by modulation of VEGF (2010)
  • Author(s): Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton DR
  • Journal Title: Blood Volume: 115(16) Issue: 16 Pages: 3398-3406
  • DOI: 10.1182/blood-2009-01-197095
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression in human idiopathic epiretinal membrane (2010)
  • Author(s): Kase S, Saito W, Ohno S, Ishida S.
  • Journal Title: Retina Volume: 30 Issue: 5 Pages: 719-723
  • DOI: 10.1097/iae.0b013e3181c59698
  • Peer Reviewed
• [Journal Article] Uveal effusion syndrome caused by choroidal invasion of malignant lymphoma (2010)
  • Author(s): Kase S, Saito W, Saito A, Ohno S.
  • Journal Title: Jpn J Ophthalmol Volume: 54(1) Issue: 1 Pages: 109-10
  • DOI: 10.1007/s10384-009-0757-5
  • NAID: 10027203684
  • Peer Reviewed
• [Journal Article] alphaB-crystallin regulation of angiogenesis by modulation of VEGF. (2010)
  • Author(s): Kase S, et al.
  • Journal Title: Blood Volume: 22 Pages: 3398-3406
  • Peer Reviewed
• [Journal Article] Cyclo-oxygenase-2 expression in human idiopathic epiretinal membrane (2010)
  • Author(s): Kase S, et al.
  • Journal Title: Retina Volume: 30 Pages: 718-723
  • Peer Reviewed
• [Journal Article] Uveal effusion syndrome caused by choroidal invasion of malignant lymphoma. (2010)
  • Author(s): Kase S, et al.
  • Journal Title: Japanese Journal of Ophthelmology Volume: 54 Pages: 109-110
  • NAID: 10027203684
  • Peer Reviewed
• [Presentation] 増殖糖尿病網膜症の繊維血管膜におけるalphaB-crystallinの発現 (2011)
  • Author(s): 董震宇、加瀬諭、安藤亮、福原淳一、レニコフ・アントン、神田敦宏、村田美幸、野田航介、齋藤航、石田晋
  • Organizer: 第115回日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2011-05-13
• [Presentation] AlphaB-crystallinによる実験的脈絡膜新生血管の制御 (2011)
  • Author(s): 加瀬諭、園田祥三、北村瑞、Stephen Ryan、David Hinton、石田晋
  • Organizer: 第115回日本眼科学会、
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2011-05-12
• [Presentation] AlphaB-crystallin in fibrovascular membrane of human proliferative diabetic retinopathy (2011)
  • Author(s): Dong Z, Kase S, Ando R, Fukuhara J, Lennikov A, Kanda A, Murata M, Noda K, Saito W, Ishida S
  • Organizer: Association for Research in Vision and Ophthalmology Annual Meeting 2011
  • Place of Presentation: Broward County Convention Center(Fort Lauderdale)
  • Year and Date: 2011-05-05