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Functional dissection of ARMS2 protein, strongly associated with susceptibility to age-related macular degeneration.

Research Project

Project/Area Number 22890007
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

KANDA Atsuhiro  北海道大学, 大学院・医学研究科, 特任助教 (80342707)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Keywords加齢黄斑変性 / LOC387715 / ARMS2
Research Abstract

We and others previously demonstrated that SNP rs10490924 within the ARMS2 gene at 10q26 is strongly associated with susceptibility to age-related macular degeneration. The goal of this study is to gain additional insights into the function of ARMS2 and its association with AMD. We identified several ARMS2 interaction proteins.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (15 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population2012

    • Author(s)
      Horie Y, et al
    • Journal Title

      Rheumatology

      Volume: (印刷中) Issue: 6 Pages: 983-6

    • DOI

      10.1093/rheumatology/ker444

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] AlphaB-crystallin expression in epiretinal membrane of human proliferative diabetic retinopathy2012

    • Author(s)
      Dong Z, Kase S, Ando R, Fukuhara J, Saito W, Kanda A, Murata M, Noda K, Ishida S.
    • Journal Title

      Retina[ Epub ahead of print]

      Volume: (In press) Issue: 6 Pages: 1190-1196

    • DOI

      10.1097/iae.0b013e318233ab9c

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors2012

    • Author(s)
      Fukuhara J, Kase S, Noda K, Kanda A, Murata M, Noda M, Ando R, Dong Z, Ishida S
    • Journal Title

      Ophthalmic Res

      Volume: 48 Issue: 1 Pages: 33-37

    • DOI

      10.1159/000335983

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement factor D in age-related macular degeneration2011

    • Author(s)
      Santon CM, Yates J, den Hollander A, Seddon J, Swaroop A, Stambolian D, Fauser, S, Hoyng, C, Kanda A, Branham K, Othman M, Chen W, Kortvely E, Chalmers K, Hayward C, Moore A, Dhillon B, Ueffing M & Wright A.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 12 Pages: 8828-8834

    • DOI

      10.1167/iovs.11-7933

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidence of association of APOE with age-related macular degeneration-a pooled analysis of 15 studies2011

    • Author(s)
      McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, Ho L, de Jong PT, Fletcher AE, Young IS, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Hingorani AD, Sofat R, Dean M, Sawitzke J, Seddon JM, Peter I, Webster AR, Moore AT, Yates JR, Cipriani V, Fritsche LG, Weber BH, Keilhauer CN, Lotery AJ, Ennis S, Klein ML, Francis PJ, Stambolian D, Orlin A, Gorin MB, Weeks DE, Kuo CL, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Wright AF, Hayward C, Baird PN, Guymer RH, Attia J, Thakkinstian A & Silvestri G
    • Journal Title

      Hum Mutat

      Volume: 32 Issue: 12 Pages: 1407-1416

    • DOI

      10.1002/humu.21577

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variations in Apolipoprotein E frequency with age in a pooled analysis of a large group of older people2011

    • Author(s)
      McKay GJ, Silvestri G, Chakravarthy U, Dasari S, Fritsche LG, Weber BH, Keilhauer CN, Klein ML, Francis PJ, Klaver CC, Vingerling JR, Ho L, De Jong PT, Dean M, Sawitzke J, Baird PN, Guymer RH, Stambolian D, Orlin A, Seddon JM, Peter I, Wright AF, Hayward C, Lotery AJ, Ennis S, Gorin MB, Weeks DE, Kuo CL, Hingorani AD, Sofat R, Cipriani V, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Yates JR, Webster AR, Moore AT, Seland JH, Rahu M, Soubrane G, Tomazzoil L, Topouzis F, Vioque J, Young IS, Fletcher AE & Patterson CC
    • Journal Title

      Am J Epidemiol

      Volume: 173 Issue: 12 Pages: 1357-1364

    • DOI

      10.1093/aje/kwr015

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue factor expression in human pteryium2011

    • Author(s)
      Ando A, Kase S, Ohashi T, Doug Z, Fukuhara J, Kanda A, Murata M, Noda K & Ishida S.
    • Journal Title

      Mol. Vis

      Volume: 17 Pages: 63-69

    • URL

      http://www.molvis.org/molvis/v17/a9/

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue factor expression in human pterygium2011

    • Author(s)
      Ando R, Kase S, Ohashi T, Dong Z, Fukuhara J, Kanda A, Murata M, Noda K, Kitaichi N, Ishida S
    • Journal Title

      Mol Vis

      Volume: 17 Pages: 63-69

    • NAID

      120005372296

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in human retina2010

    • Author(s)
      Kanda A, Stambolian D, Chen W, Curcio CA, Abecasis GR and Swaroop A.
    • Journal Title

      Mol Vis

      Volume: 16 Pages: 1317-1323

    • URL

      http://www.molvis.org/molvis/v16/a145

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic variants near TIMP3 and HDL-associated loci influence susceptibility to age-related macular degeneration. Proc. Natl. Acad2010

    • Author(s)
      Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Barats KH, Brown WL, Group CR, Brucker AJ, Orlinn A, Brown G, Ho A, Regillo C, Donsos L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BEK, Gotoh N, Yamashiro K, Ferris F, Fagerness JA, Reynolds R, Farrer LA, Kim IK ,Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, DeAngelis MM, Week DE, Zack D, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francish PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A
    • Journal Title

      Sci. USA

      Volume: 107 Issue: 16 Pages: 7401-7406

    • DOI

      10.1073/pnas.0912702107

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-associated prorenin system in the pathogenesis of retinal diseases2009

    • Author(s)
      Satofuka S, Kanda A, Ishida S.
    • Journal Title

      Front Biosci

      Volume: (In press) Issue: 1 Pages: 1443-1443

    • DOI

      10.2741/345

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 網膜疾患における(プロ)レニン受容体および関連分子の発現解析2011

    • Author(s)
      神田敦宏、野田航介、斎藤航、Anand Swaroop、石田晋
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病網膜症における(プロ)レニン受容体の血管新生活動性への関与2011

    • Author(s)
      神田敦宏
    • Organizer
      第4回Retina research meeting
    • Place of Presentation
      東京大学医科学研究所(東京)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖尿病網膜症における(プロ)レニン受容体の血管新生活動性への関与2011

    • Author(s)
      神田敦宏
    • Organizer
      第4回Retina research meeting
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病網膜症における白血球接着分子VAP-1と蛋白分解酵素MMPsの接点2011

    • Author(s)
      野田航介、神田敦宏, ほか
    • Organizer
      第1回わかもと先進眼科医療研究会
    • Place of Presentation
      ロイヤルパークホテル(東京)
    • Year and Date
      2011-07-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 染色体10q26番上の加齢黄斑変性関連SNPと遺伝子解析2011

    • Author(s)
      神田敦宏
    • Organizer
      第15回眼科分子生物学研究会
    • Place of Presentation
      フェニックス・シーガイアリゾート(宮崎県)
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 網膜疾患における(プロ)レニン受容体および関連分子の発現解析2011

    • Author(s)
      神田敦宏, ほか
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Final Research Report
  • [Presentation] Tissue factor expression in human pterygium2011

    • Author(s)
      Ando R, Kanda A, et al.
    • Organizer
      Association for Research in Vision and Ophthalmology Annual Meeting : Fort Lauderdale
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] AlphaBcrystallin in fibrovascular membrane of human proliferative diabetic retinopathy2011

    • Author(s)
      Dong Z, Kanda A, et al.
    • Organizer
      Association for Research in Vision and Ophthalmology Annual Meeting : Fort Lauderdale
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Vitreous levels of vascular adhesion protein-1 in proliferative diabetic retinopathy2011

    • Author(s)
      Fukuhara J, Kanda A, et al.
    • Organizer
      Association for Research in Vision and Ophthalmology Annual Meeting : Fort Lauderdale
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Combined genotyping and genome-wide expression analysis of peripheral blood to identify biomarkers for age-related macular degeneration2011

    • Author(s)
      Kanda A, et al.
    • Organizer
      Association for Research in Vision and Ophthalmology Annual Meeting : Fort Lauderdale
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト翼状片におけるTissue Factorの発現2011

    • Author(s)
      安藤亮、神田敦宏, ほか
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] 増殖糖尿病網膜症の線維血管膜におけるalphaB-crystallinの発現2011

    • Author(s)
      董震宇、神田敦宏, ほか
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] 増殖糖尿病網膜症患者の硝子体液におけるVAP-1濃度2011

    • Author(s)
      福原淳一、神田敦宏, ほか
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Related Report
      2011 Final Research Report
  • [Presentation] 染色体10q26番上の加齢黄斑変性関連SNPと遺伝子解析2011

    • Author(s)
      神田敦宏, ほか
    • Organizer
      第15回眼科分子生物学研究会
    • Place of Presentation
      宮崎シーガイア(宮崎市)
    • Related Report
      2011 Final Research Report
  • [Presentation] Combined genotyping and genome-wide expression analysis of peripheral blood to identify biomarkers for age-related macular degeneration2011

    • Author(s)
      Kanda A, Chen W, Ruzycki P, Brooks M, Chew EY, Abecasis GR, Stambolian D, Swaroop A
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Broward County Convention Center (USA)
    • Related Report
      2011 Annual Research Report
  • [Book] 加齢とAMD特集「加齢黄斑変性up to date」2010

    • Author(s)
      石田晋、神田敦宏
    • Publisher
      Pharma Medica
    • Related Report
      2011 Final Research Report
  • [Book] 加齢とAMD.特集「加齢黄斑変性up to date」2010

    • Author(s)
      石田晋、神田敦宏
    • Total Pages
      4
    • Publisher
      Pharma Medica
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://eye.med.hokudai.ac.jp/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-27   Modified: 2016-04-21  

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