DNA methylation analyses to predict the treatment outcome of advanced hepatoblastoma patients.

Research Project

Project/Area Number	22890008
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pediatric surgery
Research Institution	Hokkaido University
Principal Investigator	HONDA Shohei 北海道大学, 北海道大学病院, 医員 (90588089)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000) Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000) Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Keywords	肝芽腫 / DNAメチル化異常 / 予後予測分子マーカー / DNAメチル化 / 予後予測因子
Research Abstract	To establish novel prognostic markers for advanced hepatoblastoma patients, we examined the methylation status of candidate tumor suppressor genes located in the shortest overlap region of deletion found in hepatoblastoma tumors detected by SNPs array analysis. Hypermethylation of a candidate gene was found in hepatoblastoma cell lines, although hepatoblastoma tumor samples did not show any aberration of the methylation status.