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Undersulfation of chondroitin sulfate and abnormal cartilage tissue by the signaling of the receptor of PTH/PTHrP

Research Project

Project/Area Number 22890009
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTsurumi University (2011)
Hokkaido University (2010)

Principal Investigator

WADA Satoshi  鶴見大学, 歯学部, 学部助手 (20581119)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,691,000 (Direct Cost: ¥2,070,000、Indirect Cost: ¥621,000)
Fiscal Year 2011: ¥1,131,000 (Direct Cost: ¥870,000、Indirect Cost: ¥261,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsコンドロイチン硫酸の低硫酸化 / PTH/PTHrPシグナル / 細胞外基質合成異常 / 軟骨組織異常 / 軟骨細胞の増殖・分化
Research Abstract

The objectives of this study are to elucidate the relationship between not only differentiation of chondrocytes and extracellular matrix, but also proliferation of them. We performed immunohistochemical analysis in cartilage of the spheno-occipital synchondrosis of BALB/c-bm/bm mice. The expression of collagen II and collagen X were expressed irregularly in the spheno-occipital synchondrosis. Additionally, the expression of alkaline phosphatase was expressed in the center of the spheno-occipital synchondrosis, whereas that of the PCNA was expressed around the spheno-occipital synchondrosis. In summary, these results presented that the differentiation of hypertrophic chondrocytes was enhanced in the center of the spheno-occipital synchondrosis, whereas the proliferation of chondrocytes was increased around the spheno-occipital synchondrosis.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion2012

    • Author(s)
      Takahashi K, Kajii TS, Tsukamoto Y, Saito F, Wada S, Sugawara-Kato Y, Iida J.
    • Journal Title

      Orthodontics & craniofacial research

      Volume: 15(2) Issue: 2 Pages: 84-91

    • DOI

      10.1111/j.1601-6343.2011.01538.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion2012

    • Author(s)
      K.Takahashi, S.Wada, et al
    • Journal Title

      Orthodontics & Craniofacial Research

      Volume: 15 Pages: 84-91

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Histological evaluation of the nasal septal cartilage in bm/bm mouse that spontaneously induces malocclusion2011

    • Author(s)
      K.Takahashi, S.Wada, et al
    • Organizer
      第70回日本矯正歯科学会大会&第4回国際会議
    • Place of Presentation
      愛知県名古屋国際会議場
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 前歯部交叉咬合自然発症マウス(BALB/c-bm/bm)の蝶後頭軟骨結合部の免疫組織学的検討2010

    • Author(s)
      和田悟史、大西康友、菅原由紀、梶井貴史、塚本祐理、斎藤文男、平林義章、飯田順一郎
    • Organizer
      第69回日本矯正歯科学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 前歯部交叉咬合自然発症マウス(BALB/c・bm/bm)の蝶後頭軟骨結合部の免疫組織学的検討2010

    • Author(s)
      和田悟史
    • Organizer
      第69回日本矯正歯科学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-09-29
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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