Undersulfation of chondroitin sulfate and abnormal cartilage tissue by the signaling of the receptor of PTH/PTHrP
| Project/Area Number |
22890009
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tsurumi University (2011)
Hokkaido University (2010) |
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Principal Investigator |
WADA Satoshi 鶴見大学, 歯学部, 学部助手 (20581119)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,691,000 (Direct Cost: ¥2,070,000、Indirect Cost: ¥621,000)
Fiscal Year 2011: ¥1,131,000 (Direct Cost: ¥870,000、Indirect Cost: ¥261,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | コンドロイチン硫酸の低硫酸化 / PTH/PTHrPシグナル / 細胞外基質合成異常 / 軟骨組織異常 / 軟骨細胞の増殖・分化 |
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| Research Abstract |
The objectives of this study are to elucidate the relationship between not only differentiation of chondrocytes and extracellular matrix, but also proliferation of them. We performed immunohistochemical analysis in cartilage of the spheno-occipital synchondrosis of BALB/c-bm/bm mice. The expression of collagen II and collagen X were expressed irregularly in the spheno-occipital synchondrosis. Additionally, the expression of alkaline phosphatase was expressed in the center of the spheno-occipital synchondrosis, whereas that of the PCNA was expressed around the spheno-occipital synchondrosis. In summary, these results presented that the differentiation of hypertrophic chondrocytes was enhanced in the center of the spheno-occipital synchondrosis, whereas the proliferation of chondrocytes was increased around the spheno-occipital synchondrosis.
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Report
(3 results)
Research Products
(5 results)
