The functional analysis by structural change of Chromogranin in the neuropsychiatric diseases
| Project/Area Number |
22890026
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | クロモグラニン / 関連解析 / SNP / 統合失調症 / 筋萎縮性側索硬化症 / SOD1 / KOマウス |
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| Research Abstract |
In our previous genome-wide association studies, a significant association with schizophrenia was observed at the chromogranin B (CHGB) gene locus. CHGB is a widespread family of proteins in the neurosystem, whose function is guiding the sorting and secretion of neuropeptides. In this study, I perform to functional analysis of CHGB using human sample and genetically modified animal. I confirmed that the gene variation of CHGB was significantly related to schizophrenia using a large-scale sample. Furthermore, I found that the plasma CHGB protein level is high in a schizophrenia patient, and the plasma CHGB protein level related to the severity of the stress reaction.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] A two-stage case-control association study between the tryptophan hydroxylase2 (TPH2) gene and schizophrenia in a Japanese population2012
Author(s)
Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
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Journal Title
URL
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Peer Reviewed
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[Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia2012
Author(s)
Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(1)
Issue: 1
Pages: 30-37
DOI
Related Report
Peer Reviewed
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[Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population2012
Author(s)
Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
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Journal Title
Schizophr Res
Volume: Feb17(Epub ahead of print)
Related Report
Peer Reviewed
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[Presentation] SLC1A1遺伝子多型と統合失調症との関連解析2011
Author(s)
飯田周平,堀内泰江,飯嶋良味,石黒浩毅,稲田俊也,渡部雄一郎,染谷俊幸,氏家寛,岩田仲生,尾崎紀夫,功刀浩,栃木衛,糸川昌成,新井誠,新里和弘,入谷修司,柿田明美,高崎均,那波宏之,有波忠雄
Organizer
第56回日本人類遺伝学会・第11回東アジア人類遺伝学会共同大会
Place of Presentation
幕張メッ
Year and Date
2011-11-12
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[Presentation] SLC1A1遺伝子多型と統合失調症との関連解析2011
Author(s)
飯田周平, 堀内泰江, 飯嶋良味, 石黒浩毅, 稲田俊也, 渡部雄一郎, 染谷俊幸, 氏家寛, 岩田仲生, 尾崎紀夫, 功刀浩, 栃木衛, 糸川昌成, 新井誠, 新里和弘, 入谷修司, 柿田明美, 高崎均, 那波宏之, 有波忠雄
Organizer
第56回日本人類遺伝学会・第11回東アジア人類遺伝学会共同大会
Place of Presentation
幕張メッセ(千葉県)
Related Report
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