Epigenetic regulation of pancreatic beta cell function by Pdx1 transcription factor complex
| Project/Area Number |
22890027
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Gunma University |
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Principal Investigator |
ARAKI Osamu 群馬大学, 医学部, 医員 (80589482)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | 糖尿病 / 膵β細胞 / 転写因子 / エピジェネティクス / 発現制御 |
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| Research Abstract |
Pancreatic duodenal homeobox-1 protein (Pdx1) is a transcription factor that plays a critical role in the regulation of pancreatic islet development and insulin gene expression. This study aimed to identify Pdx1 transcription factor complex and characterize its physiological roles in the regulation of insulin gene transcription and epigenetic control of mature beta cell function. The results of this study lead to exploring the underlined mechanism of beta cell failure in diabetes, and identifying the epigenetic hallmark for mature functioning beta cells useful for the characterization of beta cell differentiation and regeneration.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Association between accumulation of visceral fat and the combination of β 3adrenergic receptor Trp64Arg, β 2adrenergic receptor Arg16Gly and uncoupling protein 1-3826A>G polymorphisms detected by Smart Amplification Process 22011
Author(s)
Tsunekawa K, Yanagawa Y, Aoki T, Morimura T, Araki O, Ogiwara T, KawaiY, Mitani Y, Lezhava A, Yanagawa M, Hayashizaki Y, Murakami M
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Journal Title
Endocr J
Volume: 58
Pages: 1079-1086
NAID
Related Report
Peer Reviewed
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