Epigenetic regulation of pancreatic beta cell function by Pdx1 transcription factor complex

• Project/Area Number: 22890027
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Gunma University
• Principal Investigator: ARAKI Osamu 群馬大学, 医学部, 医員 (80589482)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 糖尿病 / 膵β細胞 / 転写因子 / エピジェネティクス / 発現制御

Research Abstract

Pancreatic duodenal homeobox-1 protein (Pdx1) is a transcription factor that plays a critical role in the regulation of pancreatic islet development and insulin gene expression. This study aimed to identify Pdx1 transcription factor complex and characterize its physiological roles in the regulation of insulin gene transcription and epigenetic control of mature beta cell function. The results of this study lead to exploring the underlined mechanism of beta cell failure in diabetes, and identifying the epigenetic hallmark for mature functioning beta cells useful for the characterization of beta cell differentiation and regeneration.

Research Products

• [Journal Article] Association between accumulation of visceral fat and the combination of β 3adrenergic receptor Trp64Arg, β 2adrenergic receptor Arg16Gly and uncoupling protein 1-3826A>G polymorphisms detected by Smart Amplification Process 2 (2011)
  • Author(s): Tsunekawa K, Yanagawa Y, Aoki T, Morimura T, Araki O, Ogiwara T, KawaiY, Mitani Y, Lezhava A, Yanagawa M, Hayashizaki Y, Murakami M
  • Journal Title: Endocr J Volume: 58 Pages: 1079-1086
  • NAID: 10030392602
  • Peer Reviewed
• [Journal Article] Association between accumulation of visceral fat and the combination of .BETA.3 adrenergic receptor Trp64Arg, .BETA.2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2 (2011)
  • Author(s): Tsunekawa K, et al.
  • Journal Title: Endocrine Journal Volume: 58 Issue: 12 Pages: 1079-1086
  • DOI: 10.1507/endocrj.EJ11-0148
  • NAID: 130004443674
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Presentation] C/EBPα, PPARγを介した甲状腺ホルモンによる脂肪細胞分化誘導機構 (2011)
  • Author(s): 荒木修
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: ロイトン札幌(札幌市)
  • Year and Date: 2011-05-21
• [Presentation] C/EBPα,PPARγを介した甲状腺ホルモンによる脂肪細胞分化誘導機構 (2011)
  • Author(s): 荒木修
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: ロイトン札幌(札幌市)
  • Year and Date: 2011-05-21
• [Presentation] C/EBPα, PPARγを介した甲状腺ホルモンによる脂肪細胞分化誘導機構の解析 (2011)
  • Author(s): 荒木修
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際展示場(神戸市)
  • Year and Date: 2011-04-21
• [Presentation] C/EBPα,PPARγを介した甲状腺ホルモンによる脂肪細胞分化誘導機構の解析 (2011)
  • Author(s): 荒木修
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際展示場(神戸市)
  • Year and Date: 2011-04-21