Research Project
Grant-in-Aid for Research Activity Start-up
Pancreatic duodenal homeobox-1 protein (Pdx1) is a transcription factor that plays a critical role in the regulation of pancreatic islet development and insulin gene expression. This study aimed to identify Pdx1 transcription factor complex and characterize its physiological roles in the regulation of insulin gene transcription and epigenetic control of mature beta cell function. The results of this study lead to exploring the underlined mechanism of beta cell failure in diabetes, and identifying the epigenetic hallmark for mature functioning beta cells useful for the characterization of beta cell differentiation and regeneration.
All 2011
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)
Endocr J
Volume: 58 Pages: 1079-1086
10030392602
Endocrine Journal
Volume: 58 Issue: 12 Pages: 1079-1086
10.1507/endocrj.EJ11-0148
130004443674