| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Research Abstract |
Niemann-Pick C1 like 1(NPC1L1) is known to play an important role in the intestinal cholesterol absorption and biliary cholesterol re-absorption. In the present study, we revealed that mRNA expression of NPC1L1 is increased by female hormone(estrogen) in estrogen receptorα(ERα)-expressing cells. In addition, we found the novel function of NPC1L1 as a negative regulator of protein expression and secretion of Niemann-Pick C2(NPC2), which controls intracellular cholesterol trafficking and promotes biliary cholesterol secretion. These results would be important to consider the relationship between the gender difference in the expression level of NPC1L1 and the benefit of treatment for dyslipidemia.
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