Role of lysophosphatidic acid receptor LPA4 in the progression of metabolic syndrome

• Project/Area Number: 22890034
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: YANAGIDA Keisuke 東京大学, 大学院・医学系研究科, 助教 (00583882)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: 脂質 / シグナル伝達 / 糖尿病

Research Abstract

Lysophosphatidic acid(LPA) is a bioactive lipid mediator eliciting diverse biological functions though its specific G protein-coupled receptors. Although we have identified the fourth LPA receptor LPA4, little is known about physiological or pathological role of LPA4. Here we have revealed that LPA4 is involved in obesity-associated insulin resistance and fatty liver by using LPA4-deficient mice.

Research Products

• [Journal Article] Non-Edg family LPA receptors : the cutting edge of LPA research (2011)
  • Author(s): Yanagida, K., Ishii, S.
  • Journal Title: J.Biochem. Volume: 150 Issue: 3 Pages: 223-232
  • DOI: 10.1093/jb/mvr087
  • NAID: 10030587104
  • Peer Reviewed
• [Journal Article] Non-Edg family LPA receptors : the cutting edge of LPA research (2011)
  • Author(s): Keisuke Yanagida
  • Journal Title: Journal of Biochemistry Volume: 150 Pages: 223-232
  • NAID: 10030587104
  • Peer Reviewed
• [Journal Article] LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis (2010)
  • Author(s): Sumida, H., Noguchi, K., Kihara, Y., Abe, M., Yanagida, K., Hamano, F., Sato, S., Tamaki, K., Morishita, Y., Kano, MR., Iwata, C., Miyazono, K., Sakimura, K., Shimizu, T., and Ishii, S
  • Journal Title: Blood Volume: 116 Issue: 23 Pages: 5060-5070
  • DOI: 10.1182/blood-2010-03-272443
  • Peer Reviewed
• [Journal Article] The G protein-coupled receptor T-cell death-associated gene8 (TDAG8) facilitates tumor development by serving as anextracellular pH sensor (2010)
  • Author(s): Ihara, Y., Kihara, Y., Hamano, F., Yanagida, K., Morishita, Y., Kunita, A., Yamori, T., Fukayama, M., Aburatani, H., Shimizu, T., and Ishii, S
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Issue: 40 Pages: 17309-17314
  • DOI: 10.1073/pnas.1001165107
  • Peer Reviewed
• [Journal Article] リゾホスファチジン酸受容体研究Update (2010)
  • Author(s): 柳田圭介、石井聡
  • Journal Title: 医学のあゆみ Volume: 233巻 Pages: 807-811
• [Journal Article] LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis (2010)
  • Author(s): Hayakazu Sumida
  • Journal Title: Blood Volume: 116 Pages: 5060-5070
  • Peer Reviewed
• [Journal Article] The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor (2010)
  • Author(s): Yuichiro Ihara
  • Journal Title: Proceedings of National Academy of Sciences Volume: 107 Pages: 17309-17314
  • Peer Reviewed
• [Presentation] メタボリックシンドロームにおけるリゾホスファチジン酸受容体LPA4の病態生理機能 (2011)
  • Author(s): 柳田圭介
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館、京都府・京都市
  • Year and Date: 2011-09-23
• [Presentation] メタボリックシンドロームにおけるリゾホスファチジン酸受容体LPA4の病態生理機能 (2011)
  • Author(s): 柳田圭介
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府・京都市)
  • Year and Date: 2011-09-23
• [Presentation] Functional analysis of p2y5/LPA6 receptors with missense mutations identified in familial hypotrichosis/woolly hair patients (2011)
  • Author(s): Keisuke Yanagida
  • Organizer: FASEB summer research conferences
  • Place of Presentation: ルッカ・イルシオッコ、(イタリア)
• [Presentation] Functional analysis of p2y5/LPA6 receptors with missense mutations identified in familial hypotrichosis/woolly hair patients (2011)
  • Author(s): Keisuke Yanagida
  • Organizer: FASEB summer research conferences
  • Place of Presentation: ルッカ・イルシオッコ(イタリア)
• [Presentation] Functional characterization of human hypotrichosis/wolly hair-associated mutations in the lysophosphatidic acid receptor, p2y5/LPA6 (2010)
  • Author(s): Keisuke Yanagida
  • Organizer: 2010 Keystone Symposia Meeting Bioactive Lipids : Biochemistry and Diseases
  • Place of Presentation: 日本・ウェスティン都ホテル(京都)
  • Year and Date: 2010-06-09