Role of lysophosphatidic acid receptor LPA4 in the progression of metabolic syndrome
Project/Area Number |
22890034
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
|
Keywords | 脂質 / シグナル伝達 / 糖尿病 |
Research Abstract |
Lysophosphatidic acid(LPA) is a bioactive lipid mediator eliciting diverse biological functions though its specific G protein-coupled receptors. Although we have identified the fourth LPA receptor LPA4, little is known about physiological or pathological role of LPA4. Here we have revealed that LPA4 is involved in obesity-associated insulin resistance and fatty liver by using LPA4-deficient mice.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis2010
Author(s)
Sumida, H., Noguchi, K., Kihara, Y., Abe, M., Yanagida, K., Hamano, F., Sato, S., Tamaki, K., Morishita, Y., Kano, MR., Iwata, C., Miyazono, K., Sakimura, K., Shimizu, T., and Ishii, S
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Journal Title
Blood
Volume: 116
Issue: 23
Pages: 5060-5070
DOI
Related Report
Peer Reviewed
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[Journal Article] The G protein-coupled receptor T-cell death-associated gene8 (TDAG8) facilitates tumor development by serving as anextracellular pH sensor2010
Author(s)
Ihara, Y., Kihara, Y., Hamano, F., Yanagida, K., Morishita, Y., Kunita, A., Yamori, T., Fukayama, M., Aburatani, H., Shimizu, T., and Ishii, S
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 107
Issue: 40
Pages: 17309-17314
DOI
Related Report
Peer Reviewed
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