Investigation of involvement of chemokines and chemokine receptors in cutaneous lymphoma

• Project/Area Number: 22890044
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: MIYAGAKI Tomomitsu 東京大学, 医学部附属病院, 助教 (50582003)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 皮膚悪性リンパ腫 / CCL11 / オートクリン / cell survival / CCL20 / CCL18 / disease marker / 微小環境 / 皮膚T細胞リンパ腫 / CCL2O / IL-17 / IL-22 / CCR6 / Th22 / 予後解析 / IL-17A / 皮膚原発未分化大細胞リンパ腫 / CCR3

Research Abstract

CCL11. CCR3 interactions induce cell survival and proliferation of CCR3+anaplastic large cell lymphoma cells through constitutive phosphorylation of ERK1/2. Interactions of CCL11 and CCR3 may be a promising target for the development of future therapies for anaplastic large cell lymphoma. CCL20 and CCL18 expression is elevated in lesional skin and serum of mycosis fungoides and Sezary syndrome, and they correlated with disease severity markers of these diseases.

Research Products

• [Journal Article] IL-22, but not IL-17, Dominant Environment in Cutaneous T cell Lymphoma (2011)
  • Author(s): Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
  • Journal Title: Clin Cancer Res Volume: 17巻 Pages: 7529-7538
  • Peer Reviewed
• [Journal Article] Eotaxin-CC Chemokine Receptor 3 Interactions Promote Survival of Anaplastic Large Cell Lymphoma Cells via ERK1/2 Activation (2011)
  • Author(s): Miyagaki T, Sugaya M, Murakami T, Asano Y, Tada Y, Kadono T, Okochi H, Tamaki K, Sato S
  • Journal Title: Cancer Res Volume: 71巻 Pages: 2056-2065
  • Peer Reviewed
• [Journal Article] Blocking MAPK signaling downregulates CCL21 in lymphatic endothelial cells and impairs contact hypersensitivity responses (2011)
  • Author(s): Miyagaki T, Sugaya M, Okochi H, Asano Y, Tada Y, Kadono T, Blauvelt A, Tamaki K, Sato S.
  • Journal Title: Invest Dermatol Volume: 131(9) Issue: 9 Pages: 1927-1935
  • DOI: 10.1038/jid.2011.135
  • Peer Reviewed
• [Journal Article] IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma (2011)
  • Author(s): 宮垣朝光
  • Journal Title: Clinical Cancer Research Volume: 17 Pages: 7529-7538
  • Peer Reviewed
• [Journal Article] High Levels of Soluble ST2 and Low Levels of IL-33 in Sera of Patients with HIV Infection. (2011)
  • Author(s): 宮垣朝光
  • Journal Title: Journal of Investigative Dermatology Volume: 131 Pages: 794-796
  • Peer Reviewed
• [Journal Article] Eotaxin-CC Chemokine Receptor 3 Interactions Promote Survival of Anaplastic Large Cell Lymphoma Cells via ERK1/2 Activation. (2011)
  • Author(s): 宮垣朝光
  • Journal Title: Cancer Research Volume: 71 Pages: 2056-2065
  • Peer Reviewed
• [Journal Article] Increased CCL18 expression in patients with cutaneous T cell lymphoma : association with disease severity and prognosis
  • Author(s): Miyagaki T, Sugaya M, Suga H, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
  • Journal Title: J Eur Acad Dermatol Venereol
  • Peer Reviewed
• [Presentation] IL-22, but not IL-17, Dominant Environment in Cutaneous T cell Lymphoma (2012)
  • Author(s): Miyagaki T
  • Organizer: The 72^<nd> Annual Meeting of the Society for Investigative Dermatology. Raleigh, NC
  • Place of Presentation: Raleigh, NC, USA
  • Year and Date: 2012-05-10
• [Presentation] CD20陽性peripheral T cell lymphoma, not otherwise specifiedの一例 (2011)
  • Author(s): 宮垣朝光
  • Organizer: 第27回皮膚悪性腫瘍学会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-04
• [Presentation] Sezary症候群に進行した菌状息肉症の1例 (2010)
  • Author(s): 宮垣朝光
  • Organizer: 第26回皮膚悪性腫瘍学会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-05
• [Presentation] Eotaxin-CCR3 interaction promotes survival of anaplastic large cell lymphoma cells via ERK1/2 activation (2010)
  • Author(s): Miyagaki T
  • Organizer: The 70^<th> Annual Meeting of the Society for Investigative Dermatology
  • Place of Presentation: Atlanta, GA, USA
  • Year and Date: 2010-05-06