Basic Study of functionality and cell differentiation of decidual macrophages targeting the development of novel clinical approach for the prediction and the therapy of preterm delivery.

• Project/Area Number: 22890045
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: NAGAMATSU Takeshi 東京大学, 医学部附属病院, 助教 (60463858)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,925,000 (Direct Cost: ¥2,250,000、Indirect Cost: ¥675,000); Fiscal Year 2011: ¥1,326,000 (Direct Cost: ¥1,020,000、Indirect Cost: ¥306,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 早産 / マクロファージ / 脱落膜 / 免疫 / 妊娠 / 共刺激分子

Research Abstract

This study aimed to investigate the relevance of decidual macrophages in the pathology of preterm delivery. We clarified that decidual macrophages have unique immunological property that promotes maternal tolerance to fetal antigen mediated by humoral factors and direct cell-to-cell interaction. Our finding proposed that this anti-inflammatory property might act as a negative factor upon preterm delivery, leading to the progression of intrauterine infection. In the analysis using mouse model, functional switching of macrophages to pro-inflammatory phenotype occurs upon intrauterine infection. The suppression of this phenotypical shift using anti-inflammatory substance can be a new strategy for the treatment of preterm delivery.

Research Products

• [Journal Article] A Possible Coagulation-Independent Mechanism for Pregnancy Loss Invo lving β(2) glycoprotein 1-Dependent Antiphospholipid Antibodies and CD1d (2012)
  • Author(s): Yuki Iwasasa
  • Journal Title: American Journal of Reproductive Immunology Volume: 66 Pages: 435-443
  • Peer Reviewed
• [Journal Article] Does the classical M1/M2 dichotomy reflect the functional phenotypes of human decidual macrophages (2011)
  • Author(s): Danny J Schust, Takeshi Nagamatsu
  • Journal Title: Expert Review of Obstetrics & Gynecology Volume: 6 Issue: 4 Pages: 377-380
  • DOI: 10.1586/eog.11.34
  • Peer Reviewed
• [Journal Article] Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms (2011)
  • Author(s): Ibana JA, Schust DJ, Sugimoto J, Nagamatsu T, Greene SJ, Quayle AJ
  • Journal Title: Infect Dis Obstet Gynecol Volume: 2011 Pages: 420905-420905
  • DOI: 10.1155/2011/420905
  • Peer Reviewed
• [Journal Article] The regulation of T-cell cytokine production by ICOS-B7H2 interactions at the human fetomaternal interface (2011)
  • Author(s): Nagamatsu T, Barrier BF, Schust DJ
  • Journal Title: Immunol Cell Biol Volume: 89 Issue: 3 Pages: 417-425
  • DOI: 10.1038/icb.2010.101
  • Peer Reviewed
• [Journal Article] Inhibition of IDO1 activity by levo-1-methyl tryptophan blocks IFN-γ induced Chlamydia trachomatis persistence in human epithelial cells (2011)
  • Author(s): Ibana JA
  • Journal Title: Infect Immun Volume: 79 Issue: 11 Pages: 4425-4437
  • DOI: 10.1128/iai.05659-11
  • Peer Reviewed
• [Journal Article] Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix (2011)
  • Author(s): Buckner L
  • Journal Title: J Reprod Immunol Volume: 92 Issue: 1-2 Pages: 8-20
  • DOI: 10.1016/j.jri.2011.08.002
  • Peer Reviewed
• [Journal Article] 妊娠維持と胎盤・脱落膜細胞によるT細胞制御 (2011)
  • Author(s): 永松健
  • Journal Title: 臨床免疫・アレルギー科 Volume: 56 Pages: 374-380
• [Journal Article] The Contribution of Macrophages to Normal and Pathological Pregnancies (2010)
  • Author(s): Nagamatsu T, Schust DJ
  • Journal Title: Am J Reprod Immunol Volume: 63 Issue: 6 Pages: 460-471
  • DOI: 10.1111/j.1600-0897.2010.00813.x
  • Peer Reviewed
• [Presentation] The regulation of T-cell activity by decidual cells via PD-1 : B7-H1/-DC interaction (2011)
  • Author(s): Sayama S, Nagamatsu T, Yamashita A, Kojima S, Tomio K, Kawana K, Fujii T, Kouzuma S, Taketani Y
  • Organizer: 15^<th> Internationl Congress of Mucosal Immunology
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-07
• [Presentation] The regulation of T-cell activity by decidual cells via PD-1:B7-H1/-DC (2011)
  • Author(s): Sayama S, Nagamatsu T
  • Organizer: 15th International Congress of Mucosal Immunology
  • Place of Presentation: フランス、パリ(招待講演)
  • Year and Date: 2011-07-07
• [Presentation] Feto-Maternal Immunologic Interactions Mediated By Inducible Costimulator(ICOS) Signaling (2010)
  • Author(s): Nagamatsu T, Barrier BF, Schust DJ
  • Organizer: 66^<th> American Society for Reproductive Medicine Annual Meeting
  • Place of Presentation: Denver, USA
  • Year and Date: 2010-10-27
• [Presentation] Feto-Maternal Immunologic Interactions Mediated By Inducible Costimulator (ICOS) Signaling (2010)
  • Author(s): Takeshi Nagamatsu
  • Organizer: American Society for Reproductive Medicine Annual Meeting
  • Place of Presentation: Denver, Corolado, USA
  • Year and Date: 2010-10-24
• [Presentation] Decidual stromal cells suppress T cell activation via IDO and costimulatory pathways (2010)
  • Author(s): Nagamatsu T, Fujii T, Sayama S, Kawana K, Hyodo H, Yamashita T, Schust DJ, Kozuma S, Taketani Y
  • Organizer: International Symposium for Immunology of Reproduction/25^<th> Annual meeting of Japan Society for Immunology of Reproduction
  • Place of Presentation: Osaka, JAPAN