Bone regeneration using injectable polyurethane scaffold
| Project/Area Number |
22890055
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOSHII Toshitaka 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50583754)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | 骨再生 / ポリウレタン / Scaffold / 生体吸収性 |
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| Research Abstract |
Abstract : We observed morphology of the injectable polyurethane(PUR) scaffold in in vitro using scanning electron microscope, which demonstrated porous structures with interconnected pores. An addition of calcium phosphate(hydroxyapatite, tricalcium phosphate) to PUR resulted in good mechanical property and onsteoconductivity. In vivo injection of PUR also revealed a formation of 3-D porous scaffold, which contributed to repair of bone defects in rat femora. Lovastatin promoted new bone formation in PUR scaffold implanted in the rat femoral bone defects. A combination of injectable PUR and bone anabolic drugs can be useful approach for effective bone regeneration.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Hybrid grafting using bone marrow aspirate combined with porousβ-tricalcium phosphate and trephine bone for lumbar posterolateral spinal fusion : a prospective2012
Author(s)
Yamada T, Yoshii T, Sotome S, Yuasa M, Kato T, Arai Y, Kawabata S, Tomizawa S, Sakaki K, Hirai T, Shinomiya K
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Journal Title
comparative study versus local bone grafting
Volume: 37
Related Report
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[Journal Article] Hybrid grafting using bone marrow aspirate combined with porous ss-tricalcium phosphate and trephine bone for lumbar posterolateral spinal fusion : a prospective, comparative study versus local bone grafting2012
Author(s)
Yamada T, Yoshii T, Sotome S, Yuasa M, Kato T, Arai Y, Kawabata S, Tomizawa S, Sakaki K, Hirai T, Shinomiya K, Okawa A
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Journal Title
Spine (Phila Pa 1976)
Volume: 37
Related Report
Peer Reviewed
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