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The imaging analysis of molecules that regulate neuronal polarity

Research Project

Project/Area Number 22890061
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionNiigata University

Principal Investigator

INUTSUKA Ayumu  新潟大学, 医歯学総合研究科, 研究員 (30584776)

Co-Investigator(Renkei-kenkyūsha) KISHI Masashi  新潟大学, 医歯学系, 准教授 (60573938)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Keywords神経極性 / イメージング / SADキナーゼ / 細胞骨格 / 分子・細胞・神経生物学 / 細胞内情報伝達
Research Abstract

To identify new downstream elements of SAD kinase which is known to regulate neuronal polarity, we undertook screening and identified several candidate molecules. One of them is strongly enriched in the central nervous system, and we named it BrancK after its function on neurite branching. Elevation of BrancK activity in primary hippocampal neurons promoted neurite branching, and we found that BrancK was enriched at the sites where new microspikes emerged along neurites. Consistent with these findings, BrancK KO mouse showed reduced neurite arborization.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] SAD kinases regulate neuronal polarization through Slingshot1 protein phosphatase2012

    • Author(s)
      Ayumu Inutsuka, Masashi Kishi
    • Journal Title

      Niigata Medical Journal

      Volume: 126(2)(in press)

    • NAID

      120006749227

    • Related Report
      2011 Final Research Report
  • [Journal Article] SAD kinases regulate neuronal polarization through Slingshot 1 protein phosphatase2012

    • Author(s)
      犬束歩、岸将史
    • Journal Title

      新潟医学会雑誌

      Volume: 126(2)(未定)

    • NAID

      120006749227

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] BrancK-A novel regulator of neurite branching2011

    • Author(s)
      Ayumu Inutsuka, Shun Uemura, Manabu Abe, Kenji Sakimura, Minesuke, Yokoyama Michihiro Igarashi, Masashi Kishi
    • Organizer
      Poster, Cold Spring Harbor Conference Asia
    • Place of Presentation
      Suzhou
    • Year and Date
      2011-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] BrancK-A Novel Regulator of Neurite Branching2011

    • Author(s)
      犬束歩
    • Organizer
      Cold Spring Harbor Asia Conferences
    • Place of Presentation
      中国、蘇州
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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