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The role of the tryptophan hydroxylase 2 gene in susceptibility to schizophrenia

Research Project

Project/Area Number 22890065
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionNiigata University

Principal Investigator

NUNOKAWA Ayako  新潟大学, 医歯学総合病院, 助教 (90584607)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Keywords統合失調症 / リシークエンス / コピー数多様性 / タグ一塩基変異 / 遺伝子 / トリプトファン水酸化酵素
Research Abstract

To assess whether the tryptophan hydroxylase 2(TPH2) gene is implicated in vulnerability to schizophrenia, we conducted a two-stage case-control association study in Japanese individuals. In the first stage, we examined a total of 20 markers, including tagging single nucleotide polymorphisms(SNPs), rare missense variations identified through resequencing of protein coding regions, and common copy number variations, in 626 patients and 620 controls. In the second stage, we further investigated potentially associated SNPs in 2007 patients and 2195 controls. However, no evidence was obtained for the associations. Our results suggest that TPH2 does not confer increased susceptibility to schizophrenia in the Japanese population.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2010

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (9 results)

  • [Journal Article] Exploration of a possible association between the tryptophan hydroxylase 2(TPH2) gene and panic symptoms induced by carbon dioxide in healthy individuals2012

    • Author(s)
      Abe R, Watanabe Y, Tachibana A, Nunokawa A, Shindo M, Hasegawa N, Someya T
    • Journal Title

      Psychiatry Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A detailed association analysis between the tryptophan hydroxylase 2(TPH2) gene and autism spectrum disorders in a Japanese population2012

    • Author(s)
      Egawa J, Watanabe Y, Nunokawa A, Endo T, Kaneko N, Tamura R, Sugiyama T, Someya T
    • Journal Title

      Psychiatry Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population2012

    • Author(s)
      Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
    • Journal Title

      Schizophr Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population2012

    • Author(s)
      Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
    • Journal Title

      Schizophr Res

      Volume: 137 Issue: 1-3 Pages: 264

    • DOI

      10.1016/j.schres.2012.01.034

    • URL

      https://pure.teikyo.jp/en/publications/1796d687-c06e-4632-afa1-debe4697c80f

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population2012

    • Author(s)
      遠藤太郎、染矢俊幸
    • Journal Title

      Psychiatry Res

      Volume: (印刷中) Issue: 2-3 Pages: 320-322

    • DOI

      10.1016/j.psychres.2011.09.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploration of a possible association between the tryptophan hydroxylase 2 (TPH2) gene and panic symptoms induced by carbon dioxide in healthy individuals2012

    • Author(s)
      Abe R, et al
    • Journal Title

      Psychiatry Research

      Volume: (in press) Issue: 3 Pages: 358-359

    • DOI

      10.1016/j.psychres.2011.11.005

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case-control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1(GSTM1) gene and schizophrenia2010

    • Author(s)
      Watanabe Y, Nunokawa A, Kaneko N, Someya T
    • Journal Title

      Schizophr Res

      Volume: 124(1-3) Pages: 236-237

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Failure to find an association between myosin heavy chain 9, non-muscle(MYH9) and schizophrenia : a three-stage case-control association study2010

    • Author(s)
      Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T
    • Journal Title

      Schizophr Res

      Volume: 118(1-3) Pages: 106-112

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The dopamine D3 receptor(DRD3)gene and risk of schizophrenia : Case-control studies and an updated meta-analysis.2010

    • Author(s)
      布川綾子
    • Journal Title

      Schizophrenia Research

      Volume: VOL.116 Pages: 61-67

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acase-control association analysis of CABINI with schizophrenia in a Japanese population.2010

    • Author(s)
      渡部雄一郎
    • Journal Title

      Journal of Human Genetics

      Volume: VOL.55 Pages: 179-181

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure to find an association between myosin heavy chain 9, non-muscle(MYH9)and schizophrenia:Athree-stage case-control association study.2010

    • Author(s)
      天金秀樹
    • Journal Title

      Schizophrenia Research

      Volume: VOL.118 Pages: 106-112

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acase-control study and meta-analysis of association between acommon copy number variation of the glutathione S-transferase mu 1(GSTM 1)gene and schizophrenia(letter).2010

    • Author(s)
      渡部雄一郎
    • Journal Title

      Schizophrenia Research

      Volume: VOL.124 Pages: 236-237

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗精神病薬治療下主観的ウェルビーイング評価尺度短縮版日本語版の心理測定学的特性に関する予備的研究2010

    • Author(s)
      布川綾子
    • Organizer
      第30回日本精神科診断学会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県福岡市)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症多発罹患家系における全ゲノムコピー数多型検索2010

    • Author(s)
      金子尚史,渡部雄一郎,村竹辰之,布川綾子,染矢俊幸
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ミオシン重鎖9遺伝子は統合失調症と関連しない2010

    • Author(s)
      渡部雄一郎,天金秀樹,金子尚史,布川綾子,村竹辰之,石黒浩毅,有波忠雄,氏家寛,稲田俊也,岩田仲生,功刀浩,佐々木司,橋本亮太,糸川昌成,尾崎紀夫,染矢俊幸
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ドパミンD3受容体遺伝子と統合失調症のリスク2010

    • Author(s)
      布川綾子,渡部雄一郎,金子尚史,須貝拓朗,矢崎沙織,有波忠雄,氏家寛,稲田俊也,岩田仲生,功刀浩,佐々木司,糸川昌成,尾崎紀夫,橋本亮太,染矢俊
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] トリプトファン水酸化酵素2(TPH2)遺伝子と広汎性発達障害との関連解析2010

    • Author(s)
      江川純,渡部雄一郎,布川綾子,金子尚史,遠藤太郎,田村立,増澤菜生,杉山登志郎,染矢俊幸
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] ドパミンD3受容体遺伝子と統合失調症のリスク2010

    • Author(s)
      布川綾子
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉 (福岡県北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症多発罹患家系における全ゲノムコピー数多型検索2010

    • Author(s)
      金子尚史
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県北九州市
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミオシン重鎖9遺伝子は統合失調症と関連しない2010

    • Author(s)
      渡部雄一郎
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] トリプトファン水酸化酵素2(TPH2)遺伝子と広汎性発達障害との関連解析2010

    • Author(s)
      江川純
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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