The role of the tryptophan hydroxylase 2 gene in susceptibility to schizophrenia
| Project/Area Number |
22890065
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
NUNOKAWA Ayako 新潟大学, 医歯学総合病院, 助教 (90584607)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | 統合失調症 / リシークエンス / コピー数多様性 / タグ一塩基変異 / 遺伝子 / トリプトファン水酸化酵素 |
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| Research Abstract |
To assess whether the tryptophan hydroxylase 2(TPH2) gene is implicated in vulnerability to schizophrenia, we conducted a two-stage case-control association study in Japanese individuals. In the first stage, we examined a total of 20 markers, including tagging single nucleotide polymorphisms(SNPs), rare missense variations identified through resequencing of protein coding regions, and common copy number variations, in 626 patients and 620 controls. In the second stage, we further investigated potentially associated SNPs in 2007 patients and 2195 controls. However, no evidence was obtained for the associations. Our results suggest that TPH2 does not confer increased susceptibility to schizophrenia in the Japanese population.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population2012
Author(s)
Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population2012
Author(s)
Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
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Journal Title
Schizophr Res
Volume: 137(1-3)
Issue: 1-3
Pages: 264-266
DOI
Related Report
Peer Reviewed
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[Journal Article] Failure to find an association between myosin heavy chain 9, non-muscle(MYH9) and schizophrenia : a three-stage case-control association study2010
Author(s)
Amagane H, Watanabe Y, Kaneko N, Nunokawa A, Muratake T, Ishiguro H, Arinami T, Ujike H, Inada T, Iwata N, Kunugi H, Sasaki T, Hashimoto R, Itokawa M, Ozaki N, Someya T
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Journal Title
Schizophr Res
Volume: 118(1-3)
Pages: 106-112
Related Report
Peer Reviewed
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[Presentation] ミオシン重鎖9遺伝子は統合失調症と関連しない2010
Author(s)
渡部雄一郎,天金秀樹,金子尚史,布川綾子,村竹辰之,石黒浩毅,有波忠雄,氏家寛,稲田俊也,岩田仲生,功刀浩,佐々木司,橋本亮太,糸川昌成,尾崎紀夫,染矢俊幸
Place of Presentation
リーガロイヤルホテル小倉(北九州市)
Year and Date
2010-10-09
Related Report
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[Presentation] ドパミンD3受容体遺伝子と統合失調症のリスク2010
Author(s)
布川綾子,渡部雄一郎,金子尚史,須貝拓朗,矢崎沙織,有波忠雄,氏家寛,稲田俊也,岩田仲生,功刀浩,佐々木司,糸川昌成,尾崎紀夫,橋本亮太,染矢俊
Place of Presentation
リーガロイヤルホテル小倉(北九州市)
Year and Date
2010-10-09
Related Report
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