A structural study towards the understanding of the roles of Archaeal ESCRT in cell division.

• Project/Area Number: 22890071
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: University of Toyama
• Principal Investigator: OBITA Takayuki 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (30578696)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: ESCRT / 細胞分裂 / X線結晶構造解析 / NMR / 古細菌

Research Abstract

We have determined the structure of the beta domain and the helical domain of CdvA, and have found that the beta domain forms PRC barrel fold and the helical domain forms a novel structure fold.

Research Products

• [Journal Article] Shaw MK, Chong PL, Williams RL, Bell SD. (2011)
  • Author(s): Samson RY, Obita T, Hodgson B
  • Journal Title: Molecular Cell Volume: 41-2 Pages: 186-196
  • Peer Reviewed
• [Journal Article] Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division (2011)
  • Author(s): Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD
  • Journal Title: Molecular Cell Volume: 41(2) Pages: 186-96
  • Peer Reviewed
• [Journal Article] Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division. (2011)
  • Author(s): Samson RY, Obita T, et al
  • Journal Title: Molecular Cell Volume: 41(2) Pages: 186-196
  • Peer Reviewed
• [Presentation] 古細菌の細胞分裂におけるESCRTの役割の構造基盤研究 (2011)
  • Author(s): 帯田孝之
  • Organizer: 大阪大学蛋白研セミナー
  • Place of Presentation: 大阪大学
  • Year and Date: 2011-01-13
• [Presentation] 古細菌の細胞分裂におけるESCRTの役割の構造基盤研究 (2011)
  • Author(s): 帯田孝之
  • Organizer: 蛋白研セミナー
  • Place of Presentation: 大阪大学蛋白質研究所
  • Year and Date: 2011-01-12
• [Presentation] Structural studies of the interaction between Vps4 and ESCRT-III (2010)
  • Author(s): 帯田孝之
  • Organizer: 神戸大学GCOEセミナー
  • Place of Presentation: 神戸大学
  • Year and Date: 2010-07-21
• [Remarks]
  • URL: http://www.pha.u-toyama.ac.jp/phypha2/index-j.html
• [Remarks]
  • URL: http://www.pha.u-toyama.ac.jp/phypha2/index-j.html