| Project/Area Number |
22890073
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
MATSUSHITA Takashi Kanazawa University, 医学系, 助教 (60432126)
|
|---|
| Project Period (FY) |
2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
|
|---|
| Keywords | 強皮症 / B細胞 / IL-10 / 制御性B細胞 / GVHD |
|---|
| Research Abstract |
CD19 knockout mouse lack regulatory B cell. Therefore, this mouse is good tool for investigating regulatory B cell. We transferred CD19 knockout B10. D2 bone marrow into Balb/c recipient mice. These mice developed mild sclerodermatous GVHD comparing wildtype mice. While CD19 knockout Balb/c recipient mice which were transferred B10. D2 bone marrow were developed more severe sclerodermatous GVHD than that of wild type mice. These results indicate regulatory B cell is more critical for recipient immune response.
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