study of molecular mechanism of catechin on degradative effect of growth factor receptor and suppressive effect of tumor growth

Research Project

Project/Area Number	22890074
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	University of Fukui
Principal Investigator	YOSHIMURA Hitoshi 福井大学, 医学部, 助教 (40362917)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000) Fiscal Year 2010: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
Keywords	癌 / シグナル伝達 / 蛋白質
Research Abstract	Pletelet derived growth factor receptor(PDGFR) is one of the molecule target for cancer treatment. Cathechin has an anti-tumor effect, and we examined the effect for PDGFR. PDGFR protein was decreased by EGCG treatment. The decrease was promoted by the inhibitor of protein synthesis, and suppressed by the inhibitor of protein degradation. PDGFR ubiquitinization was observed by the treatment with EGCG and inhibitor of protein degradation. It was suggested that PDGFR protein was decrease by EGCG treatment through the activation of ubiquitin-proteasome pathway.