The role of HER2 in Rheumatoid Arthritis therapy

• Project/Area Number: 22890076
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: University of Yamanashi
• Principal Investigator: ANDO Takashi 山梨大学, 医学工学総合研究部, 助教 (10377492)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 関節リウマチ / 滑膜 / HER2 / 関節炎モデルマウス / 抗HER2抗体

Research Abstract

Approved by the Ethics Committee in the University of Yamanashi, human synovial membrane was collected as a sample of Rheumatoid Arthritis patient on Total Knee Arthroplasty. Although there is a tendency of high expression of HER2 in rheumatoid arthritis synovial membrane samples, have yet to get a significant difference from control group. After anti-HER2 antibody(trastuzumab) treatment, the effect of suppressing synovial cell proliferation was confirmed by WST assay and the appearance of apoptotic cells were detected by FACS analysis.

Research Products

• [Journal Article] HER2/HER3 Signaling Regulates NK Cell-Mediated Cytotoxicity via MHC Class I Chain-Related Molecule A and B Expression in Human Breast Cancer Cell Lines (2012)
  • Author(s): Okita R, Mougiakakos D, Ando T, Mao Y, Sarhan D, Wennerberg E, Seliger B, Lundqvist A, Mimura K, Kiessling R
  • Journal Title: Journal of immunology Volume: 188 Pages: 2136-45
  • Peer Reviewed
• [Journal Article] Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-alpha stimulation (2012)
  • Author(s): Fujita K, Ando T, Ohba T, Wako M, SatoN, Nakamura Y, Ohnuma Y, Hara Y, Kato R, Nakao A, Haro H
  • Journal Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: 30 Pages: 599-605
  • Peer Reviewed
• [Journal Article] HER2/HER3 Signaling Regulates NK Cell-Mediated Cytotoxicity via MHC Class I Chain-Related Molecule A and B Expression in Human Breast Cancer Cell Lines (2012)
  • Author(s): Okita, R.
  • Journal Title: Journal of immunology Volume: 188 Pages: 2136-2145
  • Peer Reviewed
• [Journal Article] Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation (2012)
  • Author(s): 藤田康稚
  • Journal Title: Journal of Orthopaedic Research Volume: 30 Issue: 4 Pages: 599-605
  • DOI: 10.1002/jor.21560
  • Peer Reviewed
• [Journal Article] T cell recognition of HLA-A2 restricted tumor antigens is impaired by the oncogene HER2 (2011)
  • Author(s): Mimura K, Ando T, Poschke I, Mougiakakos D, Johansson CC, Ichikawa J, Okita R, Nishimura MI, Handke D, Krug N, Choudhury A, Seliger B, et al.
  • Journal Title: Int J Cancer Volume: 128 Pages: 390-401
  • Peer Reviewed
• [Presentation] HER2-HER3シグナルは乳癌細胞株においてMICA/Bの発現を制御する (2011)
  • Author(s): 安藤隆
  • Organizer: 第19回日本乳癌学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2011-09-03
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/orthop/research.html
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/orthop/research.html
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/orthop/research.html