Identification of biomarker and therapeutic target for lung cancer

• Project/Area Number: 22890085
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Shiga University of Medical Science
• Principal Investigator: TAKANO Atsushi 滋賀医科大学, 医学部, 特任助教 (50582607)
• Co-Investigator(Renkei-kenkyūsha): DAIGO Yataro 滋賀医科大学, 医学部, 特任教授 (30345029)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2011: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000); Fiscal Year 2010: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
• Keywords: 肺がん / バイオマーカー / 癌 / トランスレーショナルリサーチ

Research Abstract

Immunohistochemical analysis showed that LASEP3 was over-expressed in lung cancers. In addition, a high level of LASEP3 expression was associated with poor prognosis for NSCLC patients. The proportion of serum LASEP3-positive cases was 61. 8% of NSCLCs, while 5. 5% of healthy volunteers were falsely diagnosed. Furthermore, treatment of lung cancer cells with siRNAs against LASEP3 suppressed its expression and resulted in growth suppression of the lung cancer cells. We have identified LASEP3 as a potential target for the development of diagnostic and prognostic biomarkers for lung cancer.

Research Products

• [Journal Article] Interferon (alpha, beta and omega) receptor 2 is a prognostic biomarker for lung cancer (2012)
  • Author(s): Tanaka S, Hattori N, Ishikawa N, Horimasu Y, Deguchi N, Takano A, Tomoda Y, Yoshioka K, Fujitaka K, Arihiro K, Okada M, Yokoyama A, Kohno N
  • Journal Title: Pathobiology Volume: 79(1) Pages: 24-33
  • Peer Reviewed
• [Journal Article] Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer (2011)
  • Author(s): Masuda K, Takano A, Oshita H, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
  • Journal Title: Clin Cancer Res Volume: 17(24) Pages: 7712-22
  • Peer Reviewed
• [Journal Article] Identification of Epstein-Barr Virus-Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer (2011)
  • Author(s): Nishino R, Takano A, Oshita H, Ishikawa N, Akiyama H, Ito H, Nakayama H, Miyagi Y, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
  • Journal Title: Clin Cancer Res Volume: 17(19) Pages: 6272-6286
  • Peer Reviewed
• [Journal Article] Krebs von den Lungen-6(KL-6) is a prognostic biomarker in patients with surgically resected non-small cell lung cancer (2011)
  • Author(s): Tanaka S, Hattori N, Ishikawa N, Shoda H, Takano A, Nishino R, Okada M, Arihiro K, Inai K, Hamada H, Yokoyama A, Kohno N.
  • Journal Title: Int J Cancer
  • Peer Reviewed
• [Journal Article] Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected non-small cell lung cancer (2011)
  • Author(s): Tanaka S, Hattori N, Ishikawa N, Shoda H, Takano A, Nishino R, Okada M, Arihiro K, Inai K, Hamada H, Yokoyama A, Kohno N
  • Journal Title: Int J Cancer Volume: 130(2) Pages: 377-87
  • Peer Reviewed
• [Journal Article] Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy (2010)
  • Author(s): Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, Nakayama H, Miyagi Y, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y.
  • Journal Title: Cancer Res Volume: 70(13) Pages: 5326-36
  • Peer Reviewed
• [Journal Article] Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. (2010)
  • Author(s): Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, Nakayama H, Miyagi Y, Tsuchiya E, Kondo S, Nakamura Y, Daigo Y.
  • Journal Title: Cancer Research Volume: 70 Pages: 5326-5336
  • Peer Reviewed
• [Journal Article] Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected non-small cell lung cancer. (2010)
  • Author(s): Tanaka S, Hattori N, Ishikawa N, Shoda H, Takano A, Nshino R, Okada M, Arihiro K, Inai K, Hamada H, Yokoyama A, Kohno N.
  • Journal Title: International journal of cancer Volume: 129
  • Peer Reviewed
• [Presentation] 網羅的遺伝子発現情報解析による肺癌の新規バイオマーカーで治療標的分子であるLASEP3の同定と機能解析 (2011)
  • Author(s): 高野淳、中村祐輔、醍醐弥太郎
  • Organizer: 第56回人類遺伝学会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-11
• [Presentation] 肺癌の血清診断バイオマーカーLASEP1の同定と抗体療法の開発 (2011)
  • Author(s): 高野淳、益田健、宮城洋平、土屋永寿、河野修興、中村祐輔、醍醐弥太郎
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] Identification of LASEP3 as a new serological and prognostic biomarker for lung cancer (2011)
  • Author(s): Atsushi Takano, Yusuke Nakamura, Yataro Daigo
  • Organizer: 第9回臨床腫瘍学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-07-22
• [Presentation] Identification of LASEP3 as a new serological and prognostic biomarker for lung cancer (2011)
  • Author(s): A. Takano, Y. Nakamura, Y. Daigo
  • Organizer: 2011 ASCO Annual meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-06-06
• [Presentation] 滋賀医科大学病院における緩和ケアチームの取り組みと大学病院における緩和ケアの考察 (2011)
  • Author(s): 高野淳、小林遊、龍神慶、服部聖子、千葉幹夫、森田幸代、遠藤善裕、醍醐弥太郎
  • Organizer: 第109回日本内科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-17
• [Presentation] Identification of a lung cancer growth factor (2011)
  • Author(s): Atsushi Takano, Ken Masuda, Yohei Miyagi, Eiju Tsuchiya, Nobuoki Kohno, Yusuke Nakamura, Yataro Daigo
  • Organizer: LASEP1 as a serological and prognostic biomarker and a therapeutic target 102nd AACR Annual meeting
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-04-05
• [Presentation] Identification of a lung cancer growth factor, LASEP1 as a serological and prognostic biomarker and a therapeutic target (2011)
  • Author(s): Atsushi Takano, Ken Masuda, Yohei Miyagi, Eiju Tsuchiya, Nobuoki Kohno, Yusuke Nakamura, Yataro Daigo
  • Organizer: 102nd AACR Annual meeting
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-04-05
• [Presentation] Characterization of a lung cancer growth factor, LASEP1 as a serological biomarker and a therapeutic target (2011)
  • Author(s): Atsushi Takano, Ken Masuda, Yohei Miyagi, Eiju Tsuchiya, Nobuoki Kohno, Yusuke Nakamura, Yataro Daigo
  • Organizer: 102th AACR meeting
  • Place of Presentation: 米国、オーランド
  • Year and Date: 2011-04-05
• [Presentation] 肺癌の新規バイオマーカーで治療標的分子であるLASEP1の機能解析 (2010)
  • Author(s): 高野淳、中村祐輔、醍醐弥太郎
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-23
• [Presentation] 肺癌の血清診断バイオマーカーLASEP1の同定と抗体療法の開発 (2010)
  • Author(s): Atsushi Takano, Yataro Daigo, Yusuke Nakamura
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 日本、大阪
  • Year and Date: 2010-09-23
• [Presentation] Integrated Genomics-based Discovery of New Oncoproteins as a Biomarker and a Molecular Target for Lung Cancer (2010)
  • Author(s): Atsushi Takano, Yataro Daigo, Yusuke Nakamura
  • Organizer: ASCO 2010 Annual meeting
  • Place of Presentation: 米国、シカゴ
  • Year and Date: 2010-06-05
• [Book] 分子標的治療薬.最新の選び方・使い方. II(Q12小分子化合物2エルロチニブ) (2011)
  • Author(s): 高野淳、醍醐弥太郎
  • Total Pages: 240
  • Publisher: 総合医学社
• [Book] 分子標的治療薬-最新の選び方・使い方-II (2011)
  • Author(s): 高野淳、醍醐弥太郎
  • Total Pages: 5
  • Publisher: 総合医学社