| Project/Area Number |
22890090
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
NISHI Hitoo Kyoto University, 医学研究科, 研修員 (70583194)
|
|---|
| Project Period (FY) |
2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,885,000 (Direct Cost: ¥1,450,000、Indirect Cost: ¥435,000)
Fiscal Year 2010: ¥1,885,000 (Direct Cost: ¥1,450,000、Indirect Cost: ¥435,000)
|
|---|
| Keywords | MicroRNA / エクソソーム / 虚血性心疾患 / microRNA |
|---|
| Research Abstract |
Serum levels of cardiac specific microRNAs in patients with ischemic heart disease were quantified by real-time PCR and consequently, miR-1 and miR-133a were found to be up-regulated. It was also demonstrated that A23187 could increase microRNA levels in the culture medium of H9C2 rat myoblast cells in a dose-dependent manner, and microRNAs contained in exosomes might be incorporated into cells and function in the recipient cells.
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