A novel organ preservation technique for small-for-size graft in liver transplantation : Venous Systemic Nitric Oxide with Oxygen Gaseous Persufflation.

• Project/Area Number: 22890094
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: YAGI Shintaro 京都大学, 医学研究科, 助教研究者 (60447969)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 過少グラフト / 一酸化窒素 / 生体肝移植 / 門脈血流 / 臓器保存 / 酸素 / 肝移植

Research Abstract

Anitric oxide(NO) with oxygen gaseous persufflation is a novel and safe preservation method for small-for-size graft liver transplantation, not only alleviating graft injury via anti-inflammatory conditions, but also improving microcirculation and bileductule damage.

Research Products

• [Journal Article] Impact of venous systemic oxygen persufflation supplemented with nitric oxide gas on cold stored warm ischaemia-damaged experimental liver grafts (2012)
  • Author(s): Srinivasan K, Yagi S(5人略2番目)
  • Journal Title: Liver Transpl Volume: 18巻 Issue: 2 Pages: 219-225
  • DOI: 10.1002/lt.22442
  • Peer Reviewed
• [Journal Article] Standard of hepatic vein reconstruction with patch plasty using native portal vein in adult living donor liver transplantation (2012)
  • Author(s): Mori A, Kaido T, Ogura Y, Ogawa K, Hata K, Yagi S, Yoshizawa A, Isoda H, Shibata T, Uemoto S.
  • Journal Title: Liver Transpl Volume: 17巻(In press) Issue: 5 Pages: 602-607
  • DOI: 10.1002/lt.23387
  • Peer Reviewed
• [Journal Article] Effects of Post-transplant Enteral Nutrition with an Immunomodulating Diet Containing Hydrolyzed Whey Peptide after Liver Transplantation (2012)
  • Author(s): Kaido T, Yagi S(5人略6番目)
  • Journal Title: World J Surg Volume: (In press) Issue: 7 Pages: 1666-1671
  • DOI: 10.1007/s00268-012-1529-9
  • Peer Reviewed
• [Journal Article] Living donor liver transplantation for recurrent hepatocellular carcinoma after liver resection (2012)
  • Author(s): Kaido T, Yagi S(6人略7番目)
  • Journal Title: Surgery Volume: 151巻 Issue: 1 Pages: 55-60
  • DOI: 10.1016/j.surg.2011.06.032
  • Peer Reviewed
• [Journal Article] Oral application of 1, 7-dimethylxanthine(paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis (2011)
  • Author(s): Klemmer I, Yagi S, Gressner OA
  • Journal Title: Hepatol Res Volume: 41巻 Issue: 11 Pages: 1094-1109
  • DOI: 10.1111/j.1872-034x.2011.00856.x
  • NAID: 10031144187
  • Peer Reviewed
• [Journal Article] Improved preservation and microcirculation with POLYSOL after partial liver transplantation (2011)
  • Author(s): Yagi S, Doorschodt B. M, Afify M, Uemoto S, Tolba R
  • Journal Title: Journal of surgical research Volume: 167巻 Issue: 2 Pages: 375-383
  • DOI: 10.1016/j.jss.2010.12.040
  • Peer Reviewed
• [Journal Article] Lower limit of the graft-to-recipient weight ratio can be safely reduced to 0.6% in adult-to-adult living donor liver transplantation in combination with portal pressure (2011)
  • Author(s): Kaido T, Mori A, Ogura Y, Hata K, Yoshizawa A, Iida T, Yagi S, Uemoto S
  • Journal Title: Transplant Proc Volume: 43 Issue: 6 Pages: 2391-2393
  • DOI: 10.1016/j.transproceed.2011.05.037
  • Peer Reviewed
• [Journal Article] Improved preservation and microcirculation with POLYSOL after partialliver transplantation (2011)
  • Author(s): Yasi S, (7人中1番目)
  • Journal Title: Journal of surgical research Volume: 167(2)
  • Peer Reviewed
• [Journal Article] Uemoto S Posttransplant bacteremia in adult living donor liver transplant recipients (2010)
  • Author(s): Iida T, Kaido T, Yagi S, Yoshizawa A, Hata K, Mizumoto M, Mori A, Ogura Y, Oike F
  • Journal Title: Liver Transpl Volume: 16(12) Issue: 12 Pages: 1379-85
  • DOI: 10.1002/lt.22165
  • Peer Reviewed
• [Journal Article] Comprehensive and innovative techniques for liver transplantation in rats : a surgical guide (2010)
  • Author(s): Hori T, Yagi S(31人中6番目)
  • Journal Title: World J Gastroenterol Volume: 16 Issue: 25 Pages: 3120-32
  • DOI: 10.3748/wjg.v16.i25.3120
  • Peer Reviewed
• [Journal Article] Posttransplant bacteremia in adult living donor liver transplant recipients. (2010)
  • Author(s): Iida T, Yagi S, (9人中3番目)
  • Journal Title: Transplantation Volume: 16(12) Pages: 1379-85
  • Peer Reviewed
• [Journal Article] Comprehensive and innovative techniques for liver transplantation in rats : a surgical guide (2010)
  • Author(s): Hori T, Yagi S, (31人中6番目)
  • Journal Title: World J Gastroenterol. Volume: 16(25) Pages: 3120-32
  • Peer Reviewed
• [Presentation] 肝移植術前感染症合併例に対する至適移植時期の検討 (2011)
  • Author(s): 八木真太郎
  • Organizer: JDDW 2011(第9回消化器外科大会)
  • Place of Presentation: 福岡国際センター他(福岡県)
  • Year and Date: 2011-10-23
• [Presentation] 肝移植術前感染症合併例の解析と至適移植時期の検討 (2011)
  • Author(s): 八木真太郎
  • Organizer: 第66回日本消化器外科総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-23
• [Presentation] A novel organ preservation technique for small-for-size grafts in liver transplantation : Venous Systemic Oxygen Persufflation.(VSOP)+Nitric Oxide Gas. (2011)
  • Author(s): Yagi S
  • Organizer: 2011 International Liver Transplant Society
  • Place of Presentation: (ヴァレンシア)スペイン
  • Year and Date: 2011-06-24
• [Presentation] A novel organ preservation technique for small-for-size grafts in liver transplantation : Venous Systemic Oxygen Persufflation. (VSOP)+Nitric Oxide Gas (2011)
  • Author(s): Yagi S
  • Organizer: 2011 International Liver Transplant Society
  • Place of Presentation: (ヴァレンシア)スペイン
  • Year and Date: 2011-06-24
• [Presentation] 心停止ドナー肝移植に対する酸素を用いた臓器保存VSOPの効果-ドナープール拡大を目指して (2011)
  • Author(s): 八木真太郎
  • Organizer: 第23回肝胆膵外科学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-06-08
• [Presentation] A novel organ preservation technique for small-for-size grafts in liver transplantation : Venous Systemic Oxygen Persufflation.(VSOP)+Nitric Oxide. (2011)
  • Author(s): Yagi S
  • Organizer: 46th European Society Surgical Research
  • Place of Presentation: (アーヘン)ドイツ
  • Year and Date: 2011-05-27
• [Presentation] A novel organ preservation technique for small-for-size grafts in liver transplantation : Venous Systemic Oxygen Persufflation. (VSOP)+Nitric Oxide Gas (2011)
  • Author(s): Yagi S
  • Organizer: 46th European Society Surgical Research
  • Place of Presentation: (アーヘン)ドイツ
  • Year and Date: 2011-05-27
• [Presentation] 生体肝移植ドナーにおける門脈分岐様式が胆管合併症に及ぼす影響についてー胆管分岐形態の検討から (2011)
  • Author(s): 八木真太郎
  • Organizer: 第111回日本外科学会
  • Year and Date: 2011-05-26
• [Presentation] 生体肝移植ドナーにおける門脈分岐様式が胆管合併症に及ぼす影響について-胆管分岐形態の検討から (2011)
  • Author(s): 八木真太郎
  • Organizer: 第111回日本外科学会
  • Place of Presentation: (紙上開催)
  • Year and Date: 2011-05-26
• [Presentation] oxygen free radicalが肝small-for-size graftに対する影響について (2010)
  • Author(s): 八木真太郎
  • Organizer: 第46回日本移植学会総会
  • Place of Presentation: (みやこめっせ)京都府
  • Year and Date: 2010-10-20
• [Presentation] Improved preservation and microcirculation with POLYSOL after small-for-size liver transplantation in rats (2010)
  • Author(s): Yagi S
  • Organizer: 8th Japan-Korea Transplantation Forum
  • Place of Presentation: (みやこめっせ)京都府
  • Year and Date: 2010-10-20
• [Presentation] Improved preservation and microcirculation with POLYSOL after small-for-size liver transplantation in rats (2010)
  • Author(s): Yagi S
  • Organizer: 8th Japan-Korea Transplantation Forum
  • Place of Presentation: 京都
  • Year and Date: 2010-10-20
• [Presentation] ラットsmall-for-size graft肝移植モデルにおける新しい臓器保存液POLYSOLの影響.虚血再灌流障害並びに肝再生の観点から (2010)
  • Author(s): 八木真太郎
  • Organizer: JDDW2010(第8回日本消化器外科学会大会)
  • Place of Presentation: (みなとみらい横浜)神奈川県
  • Year and Date: 2010-10-16
• [Presentation] 門脈圧制御による過少グラフト肝移植治療戦略.グラフト重量の限界へ (2010)
  • Author(s): 八木真太郎
  • Organizer: 第17回日本門脈圧亢進症学会
  • Place of Presentation: (富山国際会議場)富山県
  • Year and Date: 2010-09-09
• [Presentation] Impact of Oxygen Free Radicals on Liver Graft Microcirculation and Function after Partial Liver Transplantation in Rats (2010)
  • Author(s): Yagi S
  • Organizer: 2010 International Liver Transplant Society
  • Place of Presentation: (香港)中華人民共和国
  • Year and Date: 2010-06-16
• [Presentation] Impact of N-acetyl cysteine on liver graft microcirculation and function after partial liver transplantation in rats (2010)
  • Author(s): Yagi S
  • Organizer: 45th European Society for Surgical Research Congress
  • Place of Presentation: (ジュネーブ)スイス
  • Year and Date: 2010-06-12
• [Presentation] Impact of nitric oxide gaseous persufflation during cold storage on the liver grafts from NHBD in rats (2010)
  • Author(s): Kadaba P
  • Organizer: 45th European Society for Surgical Research Congress
  • Place of Presentation: (ジュネーブ)スイス
  • Year and Date: 2010-06-12
• [Presentation] Improved preservation and microcirculation with POLYSOL after small-for-size liver transplantation in rats (2010)
  • Author(s): Yagi S
  • Organizer: American Transplant Congress
  • Place of Presentation: (サンディエゴ)アメリカ合衆国
  • Year and Date: 2010-05-02
• [Presentation] Impact of N-acetyl cysteine on liver graft microcirculation and function after partial liver Transplantation in rats. (2010)
  • Author(s): Yagi S
  • Organizer: 45th European Society for Surgical Resealch Congress
  • Place of Presentation: スイス、Geneva
• [Presentation] Impact of nitric oxide gaseous persufflation during cold storage on the liver grafts from NHBD in rats. (2010)
  • Author(s): Kadaba P, Yagi S
  • Organizer: 45th European Society for Surgical Research Congress
  • Place of Presentation: スイス、Geneva
• [Presentation] Improved preservation and microcirculation with POLYSOL after small-for-size liver transplantation in rats. (2010)
  • Author(s): Yagi S
  • Organizer: American Transplant Congress 2010
  • Place of Presentation: USA, Sandiego
• [Presentation] Impact of Oxygen Free Radicals on Liver Graft Microcirculation and Function after Partial Liver Transplantation in Rats. (2010)
  • Author(s): Yagi S
  • Organizer: International Liver Transplant Society 2010
  • Place of Presentation: 中国、香港
• [Presentation] 門脈圧制御による過少グラフト肝移植治療戦略-グラフト重量の限界へ (2010)
  • Author(s): 八木真太郎
  • Organizer: 第17回日本門脈圧亢進症学会
  • Place of Presentation: 富山
• [Presentation] oxygen free radicalが肝small-for-size graftに対する影響について (2010)
  • Author(s): 八木真太郎
  • Organizer: 第46回日本移植学会総会
  • Place of Presentation: 京都
• [Presentation] ラットsmall-for-size graft肝移植モデルにおける新しい臓器保存液POLYSOLの影響-虚血再灌流障害並びに肝再生の観点から (2010)
  • Author(s): 八木真太郎
  • Organizer: 第8回日本消化器外科学会大会
  • Place of Presentation: 横浜