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In Vivo Evaluation of Deep Structure of Optic Disc in Glaucoma Using Swept Source Optical Coherence Tomography

Research Project

Project/Area Number 22890097
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

AKAGI Tadamichi  京都大学, 医学研究科, 助教 (30580112)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Keywords緑内障 / 波長走査型光干渉断層計 / 視神経乳頭深部構造
Research Abstract

The lamina cribrosa of glaucoma eyes was proved to be more vertically W-shaped than that of normal eyes by using swept source optical coherence tomography, which indicated that deformation of the lamina causing the glaucomatous optic neuropathy could be observed in vivo. Furthermore, the eyes with temporal scleral protrusion showed visual field defects more than those without. The angle of the scleral protrusion of high myopic eyes was significantly correlated to the RNFL thickness above the protrusion and the visual field severity. These indicate that some of the high myopias are affected by direct scleral compression or stretching at peripapillary region. Deep structural changes in glaucoma and peripapillary scleral changes in high myopia are related to the optic nerve damage.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (22 results) Book (2 results)

  • [Journal Article] Relationship between Fluorescein Pooling and Optical Coherence Tomographic Reflectivity of Cystoid Spaces in Diabetic Macular Edema2012

    • Author(s)
      Horii T, Murakami T, Nishijima K, Akagi T, Uji A, Arakawa N, Muraoka Y, Yoshimura N
    • Journal Title

      Ophthalmology

      Volume: 119(5) Issue: 5 Pages: 1047-1055

    • DOI

      10.1016/j.ophtha.2011.10.030

    • NAID

      120004108318

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association Between Hyperreflective Foci in the Outer Retina, Status of Photoreceptor Layer, and Visual Acuity in Diabetic Macular Edema2012

    • Author(s)
      Uji A, Murakami T, Nishijima K, Akagi T, Horii T, Arakawa N, Muraoka Y, Ellabban AA, Yoshimura N
    • Journal Title

      Am J Ophthalmol

      Volume: 153(4) Issue: 4 Pages: 710-717

    • DOI

      10.1016/j.ajo.2011.08.041

    • NAID

      120004025620

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical Coherence Tomographic Reflectivity of Photoreceptors beneath Cystoid Spaces in Diabetic Macular Edema2012

    • Author(s)
      Murakami T, Nishijima K, Akagi T, Uji A, Horii T, Ueda-Arakawa N, Muraoka Y, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53(3) Issue: 3 Pages: 1506-11

    • DOI

      10.1167/iovs.11-9231

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biometric features of peripapillary atrophy beta in eyes with high myopia2011

    • Author(s)
      Nonaka A, Hangai M, Akagi T, Mori S, Nukada M, Nakano N, Yoshimura N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(9) Issue: 9 Pages: 6706-13

    • DOI

      10.1167/iovs.11-7580

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 手術加療を要した若年プラトー虹彩の1例2011

    • Author(s)
      赤木忠道、木村友剛、諸岡諭、中野紀子、高山弘平、額田正之、池田華子、野中淳之、板谷正紀、吉村長久
    • Organizer
      第62回京大眼科同窓会学会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新しい高侵達光干渉断層計で見える強度近視眼の視神経乳頭形状の特徴2011

    • Author(s)
      赤木忠道、板谷正紀、木村友剛、諸岡諭、中野紀子、高山弘平、額田正之、池田華子、野中淳之、吉村長久
    • Organizer
      第117回京都眼科学会
    • Place of Presentation
      京都
    • Year and Date
      2011-07-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Spectral-domain OCTを用いた緑内障眼の篩状板形状解析2011

    • Author(s)
      赤木忠道、板谷正紀、木村友剛、諸岡諭、高山弘平、中野紀子、額田正之、池田華子、野中淳之、吉村長久
    • Organizer
      第22回日本緑内障学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Spectral-domain OCT radial scan画像からの視神経乳頭三次元画像構築2011

    • Author(s)
      赤木忠道、板谷正紀、野中淳之、池田華子、森哲、額田正之、中野紀子、諸岡諭、高山弘平、吉村長久
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Three-dimensional Reconstructed Imaging of Deep Structures of the Optic Disc by Optical Coherence Tomography Radial Sectioning2011

    • Author(s)
      Akagi T, Hangai M, Nonaka A, Hanako O. Ikeda, Mori S, Nukada M, Nakano N, Takayama K, Morooka S, Yoshimura N
    • Organizer
      The Association fo Research in Vision and Ophthalmology(ARVO)
    • Place of Presentation
      Fort Lauderdale, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 糖尿病黄斑浮腫におけるhyperreflective fociの局在と網膜外層の形態、視力の関係2011

    • Author(s)
      宇治彰人、村上智明、西嶋一晃、赤木忠道、堀井崇弘、荒川奈央子、村岡勇貴、吉村長久
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖尿病黄斑浮腫におけるcystoid spaceと視細胞障害との関連2011

    • Author(s)
      村上智明、西嶋一晃、赤木忠道、宇治彰人、堀井崇弘、荒川奈央子、村岡勇貴、吉村長久
    • Organizer
      第115回日本眼科学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] スペクトラルドメインOCTによる近視眼の傍乳頭網脈絡膜萎縮における深部形状の検討2011

    • Author(s)
      野中淳之、板谷正紀、赤木忠道、池田華子、森哲、額田正之、中野紀子、高山弘平、諸岡諭、木村友剛、吉村長久
    • Organizer
      第22回日本緑内障学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Annual Research Report
  • [Presentation] 視野異常を認めない早期緑内障の神経線維層欠損のOCTによる検出感度2011

    • Author(s)
      額田正之、板谷正紀、中野紀子、諸岡諭、木村友剛、赤木忠道、野中淳之、吉村長久
    • Organizer
      第22回日本緑内障学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Annual Research Report
  • [Presentation] 早期緑内障における強度近視眼と非強度近視眼の神経線維層欠損2011

    • Author(s)
      木村友剛、板谷正紀、額田正之、中野紀子、高山弘平、諸岡諭、野中淳之、赤木忠道、池田華子、吉村長久
    • Organizer
      第22回日本緑内障学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Annual Research Report
  • [Presentation] 視神経乳頭回転角と等価球面度数および視野との関連2011

    • Author(s)
      諸岡諭、板谷正紀、野中淳之、額田正之、高山弘平、中野紀子、木村友剛、赤木忠道、吉村長久
    • Organizer
      第22回日本緑内障学会
    • Place of Presentation
      秋田
    • Related Report
      2011 Annual Research Report
  • [Presentation] 補償光学走査型レーザー検眼鏡を用いた緑内障眼の篩状板孔形状解析、優秀講演賞受賞2010

    • Author(s)
      赤木忠道、板谷正紀、野中淳之、池田華子、森哲、額田正之、中野紀子、高山弘平、諸岡諭、大音壮太郎、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] In vivo morphometry of lamina cribrosa pores by using adaptive optics scanning laser ophthalmoscopy2010

    • Author(s)
      Akagi T, Hangai M, Takayama K, Nonaka A, Ooto S, Yoshimura N
    • Organizer
      European Glaucoma Society 9th Congress
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] 補償光学走査型レーザー検眼鏡を用いた緑内障眼の筋状板孔形状解析2010

    • Author(s)
      赤木忠道、板谷正紀、野中淳之、池田華子、森哲、額田正之、中野紀子、高山弘平、諸岡諭、大音壮太郎、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡(優秀講演賞受賞)
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo morphometry of lamina cribrosa pores by using adaptive optics scanning laser ophthalmoscopy2010

    • Author(s)
      Akagi T, Hangai M, Takayama K, Nonaka A, Ooto S, Yoshimura N
    • Organizer
      European Glaucoma Society 9th Congress
    • Place of Presentation
      Madrid, Spain(CERTIFICATE OF AWARD受賞)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Preperimetricおよび早期緑内障における黄斑部網膜神経節細胞層アシンメトリー解析2010

    • Author(s)
      中野紀子、板谷正紀、森哲、額田正之、高山弘平、諸岡諭、池田華子、赤木忠道、野中淳之、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] スペクトラルドメイン光干渉断層計によるpreperimetric glaucoma患者の経時的黄斑部網膜内層ひ薄化の検出2010

    • Author(s)
      森哲、板谷正紀、諸岡諭、中野紀子、高山弘平、額田正之、池田華子、赤木忠道、野中淳之、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] スペックルノイズ除去OCTによる視野異常を認めない早期緑内障における網膜神経線維層欠損の検出感度の検討2010

    • Author(s)
      額田正之、板谷正紀、諸岡諭、中野紀子、高山弘平、森哲、赤木忠道、池田華子、野中淳之、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] スペクトラルドメインOCT(RS3000)を用いた黄斑外網膜神経節細胞層複合体厚測定2010

    • Author(s)
      諸岡諭、板谷正紀、森哲、中野紀子、高山弘平、額田正之、池田華子、赤木忠道、野中淳之、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 補償光学走査レーザー検眼鏡を用いた高解像度イメージングによる緑内障眼における網膜神経線維束の観察2010

    • Author(s)
      高山弘平、大音壮太郎、板谷正紀、森哲、額田正之、諸岡諭、中野紀子、赤木忠道、池田華子、野中淳之、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 強度近視眼における緑内障性視野障害の部位と視神経乳頭回旋の関係2010

    • Author(s)
      野中淳之、板谷正紀、赤木忠道、池田華子、森哲、額田正之、中野紀子、高山弘平、諸岡諭、吉村長久
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macular ganglion cell layer asymmetry analysis in preperimetric and early glaucoma2010

    • Author(s)
      Nakano N, Hangai M, Mori S, Nukada M, Ohashi Ikeda H, Akagi T, Nonaka A, Yoshimura N
    • Organizer
      European Glaucoma Society 9th Congress
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2010 Annual Research Report
  • [Book] 特集光干渉断層計(OCT)の緑内障への応用・Spectralis HRA+OCT.あたらしい眼科28(6)2011

    • Author(s)
      赤木忠道、額田正之、中野紀子
    • Publisher
      メディカル葵出版
    • Related Report
      2011 Final Research Report
  • [Book] 特集光干渉断層計(OCT)の緑内障への応用・Spectralis HRA+OCT.あたらしい眼科2011

    • Author(s)
      赤木忠道、額田正之、中野紀子
    • Total Pages
      7
    • Publisher
      メディカル葵出版
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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