The role of KIR in infectious diseases

• Project/Area Number: 22890101
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: HIRAYASU Kouyuki Osaka University, 免疫学フロンティア研究センター, 特任研究員(常勤) (30585170)
• Project Period (FY): 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: KIR / 感染症 / NK細胞 / 病原体

Research Abstract

Killer immunoglobulin-like receptors (KIRs) have been shown to play a crucial role in regulating the activation of NK cells. To find out the novel ligand for KIRs, KIR-Ig fusion proteins were produced in this study. The binding of KIR2DS4-Ig to specific virus infected cells was detected, indicating that specific virus infected cells expressed unknown ligand for KIR2DS4.

Research Products

• [Journal Article] Abdul Salam Mudzakir Sofro, Katsushi Tokunaga. (2010)
  • Author(s): Rika Yuliwulandari, Qomariyah Sachrowardi, Humiaki Nakajima, Koichi Kashiwase, Kouyuki Hirayasu, Akihiko Mabuchi
  • Journal Title: Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia, Human Immunology 71 Pages: 697-701
  • Peer Reviewed
• [Journal Article] Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia (2010)
  • Author(s): Rika Yuliwulandari, Kouyuki Hirayasu, 他7名
  • Journal Title: Human Immunology Volume: 71 Pages: 697-701
  • Peer Reviewed
• [Presentation] 屋部登志雄、KIR遺伝子多型とマラリア重症化との関連-KIRに働く自然選択との関わり- (2011)
  • Author(s): 平安恒幸, 大橋順, 柏瀬貢一, ハナナンタチャイハッタイラ, 中伊津美, 小川篤子, 高梨美乃子, 佐竹正博, 中島一格, 荒瀬尚 徳永勝士, パタラポティクルジンタナ
  • Organizer: 第9回感染症沖縄フォーラム
  • Place of Presentation: 沖縄県(沖縄国民年金健康センター)
  • Year and Date: 2011-02-10
• [Presentation] KIR遺伝子多型とマラリア重症化との関連-KIRに働く自然選択との関わり- (2011)
  • Author(s): 平安恒幸, 他12名
  • Organizer: 第9回感染症沖縄フォーラム
  • Place of Presentation: 沖縄県(沖縄国民年金健康センター)
  • Year and Date: 2011-02-10
• [Presentation] KIR遺伝子多型と感染症 (2010)
  • Author(s): 平安恒幸
  • Organizer: 第19回日本組織適合性学会大会シンポジウム2「NKおよびクラスI認識受容体研究の最前線」
  • Place of Presentation: 東京都(東京大学)(招待講演)
  • Year and Date: 2010-09-17
• [Presentation] KIR遺伝子多型と感染症 (2010)
  • Author(s): 平安恒幸
  • Organizer: 第19回日本組織適合性学会大会
  • Place of Presentation: 東京都(東京大学)(招待講演)
  • Year and Date: 2010-09-17
• [Presentation] Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA (2010)
  • Author(s): Kouyuki Hirayasu, Jun Ohashi, Koichi Kashiwase, Izumi Naka, Hathairad Hananantachai, Atsuko Ogawa, Minoko Takanashi, Masahiro Satake, Kazunori Nakajima, Hisashi Arase, Katsushi Tokunaga, Jintana Patarapotikul, Toshio Yabe
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo (Awaji Yumebutai International Conference Center)
  • Year and Date: 2010-09-09
• [Presentation] Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA (2010)
  • Author(s): Kouyuki Hirayasu, 他12名
  • Organizer: The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 兵庫県(淡路夢舞台国際会議場)
  • Year and Date: 2010-09-09