Therapeutic perspective of tumor microenvironment in non-small-cell lung cancer.

• Project/Area Number: 22890106
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: SHINTANI Yasushi 大阪大学, 医学系・研究科, 助教 (90572983)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,964,000 (Direct Cost: ¥2,280,000、Indirect Cost: ¥684,000); Fiscal Year 2011: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 肺癌 / 癌微小環境 / 腫瘍間質 / 上皮間葉移行 / 癌間連線維芽細胞 / TGF-b / 癌幹細胞 / 抗癌剤耐性 / TGF

Research Abstract

Our recent focus has been signaling pathways that promote Epithelial to mesenchymal transition(EMT) in response to tumor microenvironment such as growth factors as well as extracellular matrix. Tumor stroma in non-small cell lung cancer(NSCLC) is of interest in the entity as both biomarkers and therapy targets. We can assume that anticancer therapeutics targeting EMT pathways and signaling elements will bring additional ways for the treatment of NSCLC.

Research Products

• [Journal Article] Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in non-small cell lung cancer (2011)
  • Author(s): Shintani Y, Okimura A, Sato K, Nakagiri T, Kadota Y, Inoue M, Sawabata N, Minami M, Ikeda N, Kawahara K, Matsumoto T, Matsuura N, Ohta M, Okumura M
  • Journal Title: Ann Thorac Surg Volume: 82 Pages: 1794-804
  • Peer Reviewed
• [Journal Article] Low dihydropyrimidine dehydrogenase correlates with prolonged survival in patients with lung adenocarcinoma treated with 5-fluorouracil (2011)
  • Author(s): Shintani Y, Inoue M, Funakoshi Y, Matsumura A, Ohta M, Maeda H, Okumura M
  • Journal Title: Anticancer Res Volume: 12 Pages: 4665-71
  • Peer Reviewed
• [Journal Article] Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in non-small cell lung cancer (2011)
  • Author(s): Shintani Y
  • Journal Title: Ann Thorac Surg Volume: 82 Pages: 1794-1804
  • Peer Reviewed
• [Journal Article] Low dihydropyrimidine dehydrogenase correlates with prolonged survival in patients with lung adenocarcinoma treated with 5-fluorouracil (2011)
  • Author(s): Shihtani Y
  • Journal Title: Anticancer Res Volume: 31 Pages: 4665-4671
  • Peer Reviewed
• [Presentation] 癌間質線維芽細胞を標的とした肺癌治療の開発 (2011)
  • Author(s): 新谷康
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-04
• [Presentation] 上皮間葉移行EMTを標的とした肺癌治療の開発 (2011)
  • Author(s): 新谷康
  • Organizer: 第20回日本癌病態治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-18
• [Presentation] 癌周囲微小環境を標的とした肺癌治療の開発 (2011)
  • Author(s): 新谷康
  • Organizer: 第111回日本外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-26
• [Presentation] Therapeutic perspective of epithelial. to-mesenchymal trasition in non-small-cell lung cancer (2011)
  • Author(s): Shintani Y
  • Organizer: 47th Annual Meeting STS(The Society of Thoracic Surgeons)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-01-31
• [Presentation] Therapeutic perspective of epithelial-to-mesenchymal transition in non-small-cell lung cancer. (2011)
  • Author(s): Y Shintani
  • Organizer: 47th Annual Meeting STS (The Society of Thoracic Surgeons)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-01-31
• [Presentation] Therapeutic perspective of epithelial. to-mesenchymal trasition in non-small-cell lung cancer (2010)
  • Author(s): Shintani Y
  • Organizer: International symposium on cancer research and therapy
  • Place of Presentation: Tokyo
  • Year and Date: 2010-11-26
• [Presentation] Therapeutic perspective of epithelial-to-mesenchymal transition in non-small-cell lung cancer. (2010)
  • Author(s): Y Shintani
  • Organizer: International symposium on cancer research and therapy (7)
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-11-26
• [Presentation] 肺癌放射線化学療法後の切除標本における上皮間葉転換EMTマーカーの検討 (2010)
  • Author(s): 新谷康
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-11-04
• [Presentation] 肺癌放射線化学療法後の切除標本における上皮間葉転換EMTマーカーの検討 (2010)
  • Author(s): 新谷康
  • Organizer: 日本肺癌学会総会(51)
  • Place of Presentation: 広島
  • Year and Date: 2010-11-04
• [Presentation] 癌周囲微小環境を標的とした肺癌治療 (2010)
  • Author(s): 新谷康
  • Organizer: 第5回肺癌ワークショップ
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-18
• [Presentation] 癌周囲微小環境を標的とした肺癌治療 (2010)
  • Author(s): 新谷康
  • Organizer: 肺癌ワークショップ(5)
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2010-09-18
• [Presentation] 上皮間葉転換EMTを標的とした肺癌治療 (2010)
  • Author(s): 新谷康
  • Organizer: 第27回日本呼吸器外科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-14
• [Presentation] 上皮間葉転換EMTを標的とした肺癌治療 (2010)
  • Author(s): 新谷康
  • Organizer: 日本呼吸器外科学会総会(27)
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-14
• [Presentation] 連行非小細胞肺癌に対する術前導入化学放射線療法後の手術成績の検討 (2010)
  • Author(s): 新谷康
  • Organizer: 第110回日本外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-10