Research of the new target for the treatment of disorders of nerves

• Project/Area Number: 22890107
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Osaka University
• Principal Investigator: OKADA Kiyoshi 大阪大学, 医学部附属病院, 医員 (40576279)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 脊髄損傷 / 末梢神経 / 再生 / Icmt / 小脳顆粒細胞 / mTOR

Research Abstract

In this research, we found that the Akt/ mTOR signaling pathway related with Icmtcontrols neurite outgrowth and neuronal apoptosis. We believe that Icmt has apotential to become a new target to treat several nervous disorders, and furtherinvestigation of the effects of Icmt may reveal new insights into nerveregeneration and the treatment of several nervous diseases and injuries.

Research Products

• [Journal Article] Akt/ mTORsignalingpathwayregulatesneuriteoutgrowthincerebellargranuleneuronsaffectedbymethylcobalamin (2011)
  • Author(s): Kiyoshi Okada, et al
  • Journal Title: Neuroscience letters Volume: 495 Pages: 201-4
  • Peer Reviewed
• [Journal Article] p70 ribosomal S6 protein kinaseの活性化とmethylcobalamin作用機序の関係 (2011)
  • Author(s): 岡田潔, 他
  • Journal Title: 末梢神経 Volume: 22(2) Pages: 309-310
  • NAID: 10030408595
  • Peer Reviewed
• [Journal Article] Akt/mTOR signaling pathway regulates neurite outgrowth in cerebellar granule neurons affected by methylcobalamin (2011)
  • Author(s): Kiyoshi Okada, et al
  • Journal Title: Neuroscience Letters Volume: 495 Pages: 201-204
  • Peer Reviewed
• [Journal Article] Methylcobalaminはmethionine synthaseを介してErk1/2、Aktを活性化し、神経軸索伸展と生存を促進する (2010)
  • Author(s): 岡田潔
  • Journal Title: 末梢神経 Volume: 21 Pages: 328-329
• [Presentation] 神経再生におけるp70 ribosamal S6protein kinaseとmethylcobalaminの関係 (2011)
  • Author(s): 岡田潔, 他
  • Organizer: 日本運動器移植・再生医学研究会
  • Place of Presentation: 福岡
  • Year and Date: 2011-09-25
• [Presentation] 神経再生におけるp70 ribosamal S6 protein kinaseとmethylcobalaminの関係 (2011)
  • Author(s): 岡田潔, 他
  • Organizer: 日本運動器移植・再生医学研究会
  • Place of Presentation: 福岡
  • Year and Date: 2011-09-25
• [Presentation] p70 ribosomal S6 protein kinaseの活性化とmethylcobalamin作用機序の関係 (2011)
  • Author(s): 岡田潔, 他
  • Organizer: 日本末梢神経学会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-09-03
• [Presentation] 特発性足根管症候群に対するT2mapping法による評価の試み (2011)
  • Author(s): 岡田潔, 他
  • Organizer: 日本整形外科学会
  • Place of Presentation: Web
  • Year and Date: 2011-05-15
• [Presentation] 特発性足根管症候群に対するT2mapping法による評価の試み (2011)
  • Author(s): 岡田潔, 他
  • Organizer: 日本整形外科学会
  • Place of Presentation: (Web開催)
  • Year and Date: 2011-05-15
• [Presentation] Akt/mTOR signaling pathway regulates neurite outgrowth in cerebellar granule neurons affected by methylcobalamin. (2010)
  • Author(s): Kiyoshi Okada
  • Organizer: Neuroscience 2010, 40th annual meeting of Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] Methylcobalamin promotes neurite outgrowth with the activation of Akt/mTOR. (2010)
  • Author(s): Kiyoshi Okada
  • Organizer: 11th Triennial Congress of the International Federation of Societies for Surgery of the Hand.
  • Place of Presentation: 新潟
  • Year and Date: 2010-11-01
• [Presentation] Akt/mTORシグナル伝達はmethylcobalaminによる小脳顆粒細胞軸索伸展を制御する (2010)
  • Author(s): 岡田潔
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2010-10-14
• [Presentation] Methylcobalamin promotes neurite outgrowth through Akt/mTOR signaling pathway in cerebellar granule neurons. (2010)
  • Author(s): Kiyoshi Okada
  • Organizer: 28th Annual Adrian E.Flatt residents and fellows conference in hand surgery
  • Place of Presentation: 新潟
  • Year and Date: 2010-10-05
• [Presentation] MethylcobalaminはAkt/mTORシグナル伝達を介して神経軸索伸展を促進する (2010)
  • Author(s): 岡田潔
  • Organizer: 第21回日本末梢神経学会
  • Place of Presentation: 新潟
  • Year and Date: 2010-09-04
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/ort/www/research8-4.html
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/ort/www/research8-4.html