Expression and function analysis of Hox genes in tooth development

• Project/Area Number: 22890117
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Okayama University
• Principal Investigator: UCHIBE Kenta 岡山大学, 岡山大学病院, 医員 (20584618)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,925,000 (Direct Cost: ¥2,250,000、Indirect Cost: ¥675,000); Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000); Fiscal Year 2010: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
• Keywords: 歯胚 / 発生 / Hox / 歯学

Research Abstract

We focused on Hox genes, which have never been reported to be included in tooth development. The expression patterns of Hox genes in developing tooth germ were determined by in situ hybridization assays. As a result, 9 of 32 analyzed genes showed spatial specific expression patterns in developing tooth.