| Project/Area Number |
22890122
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,405,000 (Direct Cost: ¥1,850,000、Indirect Cost: ¥555,000)
Fiscal Year 2011: ¥949,000 (Direct Cost: ¥730,000、Indirect Cost: ¥219,000)
Fiscal Year 2010: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
|
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| Keywords | 歯学 / 細胞・組織 / シグナル伝達 / 移植・再生医療 / 再生医学 |
|---|
| Research Abstract |
Stimulation over the opening cartilage for temporomandibular joint in rats, promote the secretion of IL-1βin the mesenchymal layer of cartilage, reduced the proteoglycan of hyaline cartilage layer of the surface cartilage and hyaluronic acid. By irradiation of a rat model of LIPUS for the opening over, a decrease in IL-1βcompared to the non-irradiated group, the increase in proteoglycan On the other hand was observed. Suppressor pathway for IL-1βof LIPUS, LIPUS pathways inhibited the enhancement of COX-2 and ERK-1/ 2 by activating integrin under inflammation, called to suppress the IL-1βhas been suggested.
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